The use of antibiotics for pyelonephritis
Pyelonephritis is the most common kidney disease caused by microbial flora, which often has a tendency to relapse, the outcome of which is chronic kidney disease. The use of modern drugs in a complex treatment regimen reduces the likelihood of recurrence, complications, and not only the relief of clinical symptoms, but also a complete recovery.
The above is true for primary pyelonephritis, it is clear that before setting similar tasks for conservative therapy, it is necessary to carry out a surgical or some other correction in order to restore an adequate flow of urine.
In general, urinary tract infections are among the twenty most common reasons for visiting a doctor. Treatment of uncomplicated pyelonephritis does not require hospitalization, a sufficiently adequate course of anti-bacterial anti-inflammatory immunomodulating therapy, followed by follow-up.
Patients with a complicated form of pyelonephritis, where the leading role in the progression of the inflammatory process is given to obstruction, are admitted to hospital.
Patients who are not able to be treated with antibiotics and other oral agents, for example, due to vomiting, are subject to inpatient treatment.
In Russia, more than 1 million new cases of pyelonephritis are registered annually, so the treatment of this nosology remains an urgent problem.
Before proceeding to the choice of antibiotic for initial therapy, it is necessary to pay attention to which pathogens most often cause one or another form of pyelonephritis.
If you look at the statistics, you can see that most forms of uncomplicated pyelonephritis are triggered by E. coli (up to 90%), Klebsiella, Enterobacter, Proteus, and Enterococci.
As for the secondary obstructive pyelonephritis - the microbial spectrum of pathogens here is much wider.
The percentage of gram-negative pathogens, including E. coli, is reduced, and gram-positive flora comes first: Staphylococci, Enterococci specimens, Pseudomonas aeruginosa.
Before you prescribe an antibiotic, you must consider the following aspects:
1. Pregnancy and lactation,
2. Allerological history
3. Compatibility of a potentially prescribed antibiotic with other drugs the patient is taking,
4. What antibiotics were taken before and for how long,
5. Where went ill pyelonephritis (assessment of the probability of a meeting with a resistant pathogen).
The dynamics after the administration of the drug is assessed after 48–72 hours, if there is no positive dynamics, including clinical and laboratory indicators, then one of three measures is performed:
• Increase the dosage of the antibacterial agent.
• The antibacterial drug is canceled and an antibiotic from another group is prescribed.
• Add another antibacterial drug that acts as a synergist, i.e. enhances the action of the first.
As soon as they receive the results of the sowing analysis on the pathogen and sensitivity to antibiotics, they correct the treatment regimen if necessary (a result is obtained, from which it is clear that the pathogen is resistant to the antibacterial agent taken).
In the outpatient setting, a broad-spectrum antibiotic is prescribed for 10–14 days, if by the end of treatment the condition and state of health returned to normal, in the general urinalysis, Nechiporenko’s test, a general blood test did not reveal any inflammatory process, 2-3 courses of uro-septic administration are prescribed. This must be done to achieve the death of infectious foci inside the kidney tissue and to prevent the formation of cicatricial defects with the loss of functional tissue.
What is step therapy
Antibiotics, prescribed for pyelonephritis, can be used in various forms: oral, infusion or intravenous.
If in the outpatient urological practice, oral administration of drugs is quite possible, with complicated forms of pyelonephritis, the introduction of antibacterial drugs intravenously is preferable for a more rapid development of the therapeutic effect and increased bioavailability.
After improvement of health, the disappearance of clinical manifestations, the patient is transferred to the oral intake. In most cases, this occurs 5–7 days after the start of treatment. The duration of therapy for this form of pyelonephritis is 10-14 days, but it is possible to prolong the course to 21 days.
Sometimes patients ask a question: “Is it possible to cure pyelonephritis without antibiotics?”
It is possible that some cases would not be fatal, but the chronization of the process (transition to a chronic form with frequent relapses) would have been ensured.
In addition, one should not forget about such terrible complications of pyelonenphritis as bacterial toxic shock, pyonephrosis, kidney carbuncle, apostematic pyelonephritis.
These conditions in urology are urgent, requiring an immediate response, and, unfortunately, the survival rate in these cases is not 100%.
Therefore, it is unreasonable to put experiments on yourself, if all the necessary means are available in modern urology.
What drugs are better for uncomplicated inflammation of the kidneys, or used antibiotics in the treatment of acute non-obstructive pyelonephritis
So, what antibiotics are used for pyelonephritis?
Drugs of choice - Fluoroquinolones.
Ciprofloxacin 500 mg 2 times a day, duration of treatment 10–12 days.
Levofloxacin (Floracid, Glevo) 500 mg 1 time per day for 10 days.
Norfloxacin (Nolitsin, Norbaktin) 400 mg 2 times a day for 10-14 days.
Ofloxacin 400 mg 2 times a day, duration 10 days (in low-weight patients, dosage 200 mg 2 times a day is possible).
If, for any reason, the prescription of the above antibiotics for pyelonephritis is not possible, drugs from the group of 2-3 generation cephalosporins are included in the scheme, for example: Cefuroxime, Cefixime.
Aminopenicillins: Amoxicillin / clavulanic acid.
Antibiotics for acute pyelonephritis or nosocomial kidney infection
For the treatment of acute complicated pyelonephritis prescribed Fluoroquinolones (Ciprofloxacin, Levofloxacin, Pefloxacin, Ofloxacin), but use the intravenous route of administration, i.e. these antibiotics for pyelonephritis also exist in injections.
Aminopenicillins: amoxicillin / clavulanic acid.
Cephalosporins, for example, Ceftriaxone 1.0 g 2 times a day, a course of 10 days,
Ceftazidime 1-2 g 3 times a day intravenously, etc.
Aminoglycosides: Amikacin 10-15 mcg per 1 kg per day - 2-3 times.
In severe cases, a combination is possible. Aminoglycoside + Fluoroquinolone, or Cephalosporin + Aminoglycoside.
Effective antibiotics for treating pyelonephritis in pregnant women and children
It is clear to everyone that for the treatment of gestational pyelonephritis such an antibacterial drug is needed, the positive effect of the use of which exceeded all possible risks, there would be no negative impact on the development of pregnancy, and in general, the side effects would be minimized.
How many days to drink antibiotics, the doctor decides individually.
As a starting treatment for pregnant women, the drug of choice is amoxicillin / clavulanic acid (protected aminopenicillins) at a dosage of 1.5–3 g per day or orally 500 mg 2-3 times a day, in a course of 7-10 days.
Cephalosporins 2-3 generations (Ceftriaxone 0.5 g 2 times a day or 1.0 g per day intravenously or intramuscularly.
Fluoroquinolones, tetracyclines, sulfanilamides are not used for the treatment of pyelonephritis in pregnant women and children.
In children, as in pregnant women, the antibiotic from the group of protected aminopenicillins is the drug of choice, the dosage is calculated according to age and weight.
In complicated cases, it is also possible treatment with Ceftriaxone, 250-500 mg 2 times a day intramuscularly, the duration of the course depends on the severity of the condition.
What are the features of antibacterial treatment of pyelonephritis in the elderly?
Pyelonephritis in age-related patients, as a rule, proceeds against the background of associated diseases:
• benign prostatic hyperplasia in men,
• atherosclerotic processes, including kidney vessels,
• arterial hypertension.
Given the duration of inflammation in the kidneys, it is possible to presuppose the multiresistance of the microbial flora, the tendency of the disease to frequent exacerbations and the more severe course.
For older patients, the antibacterial drug is chosen taking into account the functional ability of the kidneys and associated diseases.
Clinical cure with incomplete laboratory remission is allowed (i.e., the presence of leukocytes and bacteria is acceptable in urine tests).
Nitrofurans, Aminoglycosides, Polymyxins in the elderly do not prescribe.
Summing up the review of antibacterial drugs, we note that the best antibiotic for pyelonephritis is a well-chosen drug that will help you.
It’s better not to take on this business on your own, otherwise the harm done to the body can greatly exceed the benefits.
Antibiotic treatment for pyelonephritis in men and women is not fundamentally different.
Sometimes patients are asked to prescribe "antibiotics for the last generation of kidney pyelonephritis." This is a completely unreasonable request, there are drugs whose use is justified for the treatment of serious complications (peritonitis, urosepsis, etc.), but it is in no way applicable for uncomplicated forms of inflammation in the kidneys.
What else are effective drugs for the treatment of pyelonephritis
As we said above, a multicomponent regimen is used to treat pyelonephritis.
After antibiotic therapy, the reception of uroseptics is justified.
The most frequently appointed include:
Palin, Pimidel, Furomag, Furadonin, Nitroxoline, 5-NOK.
As first-line drugs for acute pyelonephritis, they are ineffective, but an additional link, after adequate treatment with antibacterial agents, works well.
The reception of uroseptics in the autumn-spring period is grounded, for the prevention of relapse, since antibiotics for chronic pyelonephritis are not used. Usually drugs from this group are prescribed courses for 10 days.
The work of the immune system in confronting microorganisms that cause inflammation of the urogenital organs, play a significant role. If the immunity worked at the proper level, perhaps the primary pyelonephritis did not have time to develop. Hence, the task of immunotherapy is to improve the body’s immune response to pathogens.
For this purpose, the following drugs are prescribed: Genferon, Panavir, Viferon, Kipferon, Cycloferon, etc.
Additionally justified reception multivitamins with microelements.
Treatment of acute pyelonephritis with antibiotics may be complicated by candidiasis (thrush), so one should not forget about antifungal drugs: Diflucan, Flucostat, Pimafucin, Nystatin, etc.
Means that improves blood circulation in the kidneys
One of the side effects of the inflammatory process is renal vascular ischemia. Do not forget that it is through the blood that drugs and nutrients that are necessary for recovery are delivered.
To remove manifestations of ischemia, apply Trental, Pentoxifylline.
Herbal medicine or how to treat herbal pyelonephritis
Considering the fact that pyelonephritis after antibiotics needs further attention, let us turn to the possibilities of nature.
Even our distant ancestors used various plants in the treatment of kidney inflammation, since already in antiquity healers possessed information about the antimicrobial, anti-inflammatory and diuretic effects of certain herbs.
The effective plants for inflammation in the kidneys include:
• Dill seeds,
• bearberry (bear ears),
• herv woolly and others.
You can buy ready-made collection of herbs from the kidneys in the pharmacy, for example, Fitonefrol, Brusniver and brew, like tea in filter bags.
As an option, it is possible to use complex herbal remedies, which include:
When treating pyelonephritis, do not forget about diet: great importance is attached to proper nutrition.
Brief description of the disease
Despite the achievements of modern medicine, pyelonephritis is still considered difficult to diagnose disease, so self-medication - especially antibiotics - at home (without a visit to the doctor) is strictly prohibited. Late initiation of therapy - or its inaccuracy - can be fatal.
Urgent contact with the clinic is necessary when the following symptoms:
- chills, accompanied by a rise in body temperature up to 39–40 degrees,
- painful sensations in the lumbar region (as a rule, they join for 2-3 days from the moment of deterioration of health) on the side of the affected kidney,
- intoxication (thirst, sweating, pallor, dryness in the mouth),
- pain on palpation of the kidneys.
Pyelonephritis is a disease that can occur at any age, but experts still distinguish three main groups of patients, whose risk of developing an illness is much higher:
- Children under 3 years old, especially girls.
- Women and men under 35 years old (women are more prone to illness).
- Older people (over 60).
The prevalence among the patients of the fair sex is due to the peculiarities of the anatomical structure and the change in their hormonal levels (for example, during pregnancy).
What are the principles of prescribing antibiotics?
When visiting a sick medical institution, the specialist, after conducting a general examination, will prescribe additional tests (for example, a complete blood and urine test).
Since pyelonephritis occurs as a result of the active growth of colonies of various microorganisms — Escherichia coli (about 49% of cases), Klebsiella and Proteus (10%), fecal enterococci (6%), and some other infectious agents — then microbiological studies are used to determine the type of pathogen. particular bacteriological seeding of biological fluid, i.e., urine). Antibiotics for inflammation of the kidneys are selected on the basis of all the above tests.
Bakposev is also used in case of recurrence of the disease, to identify the sensitivity of microbes to medical goods involved.
Often, the appointment of antibacterial drugs occurs only on the basis of the clinical picture of the disease, in order to prevent further development of the disease. In the future, after receiving the results of laboratory studies, the treatment regimen can be adjusted.
Pyelonephritis and antimicrobial therapy
The use of a course of antibiotics allows in a short time to stabilize the patient's condition, to achieve a positive clinical dynamics. The patient's temperature decreases, his health improves, signs of intoxication disappear. The condition of the kidneys is normalized, and after a few days from the moment of the start of treatment they return to normal and tests.
Often, already after 7 days of such treatment, the backpoints have negative results.
For the treatment of primary infection, short courses of antimicrobial agents are most often prescribed; health workers recommend using antibiotics for a long period of time in complicated forms of the disease.
With a general intoxication of the body, antibacterial drugs are combined with other medicines. The selected medication is replaced by another remedy if there is no improvement in the patient’s condition.
Essential drugs for kidney inflammation
From a wide list of antimicrobial agents for the treatment of pyelonephritis, medicines are selected that are most effective against the pathogen, the causative agent of the disease, and have no toxic effect on the kidneys.
Often, antibiotics of the penicillin group (Amoxicillin, Ampicillin), which are destructive for most gram-positive microorganisms and gram-negative infectious agents, become the drugs of choice. Representatives of this type of medicine are well tolerated by patients, they are also prescribed for pyelonephritis in pregnant women.
Since a number of pathogens produce specific enzymes that destroy the beta-lactam ring of the described type of antibiotics, combined penicillins protected by inhibitors are prescribed for the treatment of certain cases. Among these drugs with a wide range of effects, is Amoxiclav.
Cephalosporins are also considered to be the starting antibiotics for the relief of pyelonephritis symptoms.
Drugs of the first generation of this group are used extremely rarely. Cephalosporin row 2 and 3 types of medicines are called by many experts the most effective medical goods available (due to the length of time they are in the tissues of the patient’s organs).
Cefuroxime tablets (2nd generation) is used to treat uncomplicated acute pyelonephritis. Ceftibuten, Cefixime and Ceftriaxone (type 3) prevent the development of complicated types of the disease (the first two drugs are used orally, the last one in the list is used for injections).
Fluoroquinols and carbapenems to combat disease
Means for the treatment of inflammation of the kidneys - both in the hospital and outpatient treatment - have recently become more and more fluoroquinol group drugs:
- 1st generation drugs (Ciprofloxacin, Ofloxacin) are used orally and parenterally, characterized by low toxicity, rapid absorption and a long period of excretion from the body,
- Antibiotics Moxifloxacin, Levofloxacin (2 generations) are used in various forms of pyelonephritis in pill form and as an injection.
It should be remembered that fluoroquinols have an impressive spectrum of side effects. It is forbidden to use them in pediatrics and for the treatment of pregnant women.
Carbapenems, a class of β-lactam antibiotics having a mechanism of action similar to penicillins (Imipenem, Meropenem), deserve special mention.
Such drugs are used in cases of occurrence in patients:
- no improvement after using other types of medications,
- diseases caused by complex effects on the body of anaerobes and gram-negative aerobes.
According to the observations of experts, the clinical efficacy of these drugs is over 98%.
Aminoglycosides: Pros and Cons
In complicated forms of kidney inflammation, doctors use aminoglycoside antibiotics (Amikacin, Gentamicin, Tobramycin) in therapy regimens, often combining them with cephalosporins and penicillins.
Against the background of the high efficacy of these drugs in relation to the pyocyanic sticks, the argument against their use is a pronounced toxic effect on the kidneys and organs of hearing. The dependence of the defeat of these systems on the level of drug concentration in body fluids (blood) is proved laboratory.
To minimize the negative effects of fluoroquinols, experts prescribe a daily dose of the drug once, and with the introduction of the drug constantly monitor the level of urea, potassium, creatinine in the blood.
The interval between the primary and repeated courses of antibiotic therapy with the use of drugs in this group should be at least 12 months.
Aminoglycosides are not involved in the treatment of pregnant women and patients aged 60 years.
Three important nuances
In addition to all the above, there are a number of special moments that everyone should know about:
- Antibiotics are prescribed taking into account the response of the biological fluid secreted by the kidneys. When the balance indicator is shifted to the alkaline side, Lincomycin, Erythromycin, aminoglycoside group drugs are used.
- In case of an increased level of acidity, tetracycline and penicillin drugs are used. Vancomycin, Levomitsetin appointed, regardless of the reaction.
- If the patient has a history of chronic renal failure, antibiotics — aminoglycosides are not recommended for the treatment of pyelonephritis.
For the treatment of various forms of the disease in children, drugs are chosen with extreme caution, since not all drugs can be used at an early age. Some experts argue for the use of combined treatment regimens:
Pyelonephritis in brief
Pyelonephritis is a kidney disease of inflammatory genesis, which can occur both in the form of a primary and in the form of a secondary lesion. Most often, the primary form of the disease is characteristic of acute pyelonephritis. The secondary form is a disease that develops as a complication of other pathologies. Most affected by this ailment:
- school and teenage children,
- women of childbearing age
- men suffering from the pathology of the urogenital system (adenoma, prostatitis).
The following symptoms may indicate the presence of an inflammatory process in the kidneys:
- low back pain
- change urine's usual straw yellow color to greenish or red,
- bouts of nausea
- general weakness and malaise,
- chills and fever,
- heart palpitations and breathing.
When the first alarming symptoms appear, you should seek qualified medical assistance and in no case be self-medicated.
Features of antibacterial treatment of inflammatory diseases of the kidneys
Given the bacterial origin of the disease, pyelonephritis should be treated with antibiotics. In order to determine exactly what drugs should be used to treat the disease, it is recommended to make a bacterial urine culture with the determination of the sensitivity of the microflora to the antibiotic. In order not to waste time waiting for the results of bacterial culture, the attending physician may prescribe one of the broad-spectrum antibiotics for the treatment of pyelonephritis.
Most often used:
- Piperacilin is a number of modern antibiotics for the treatment of pyelonephritis, belonging to the fifth generation, in the pharmacy chain are presented under the name Isipen, Picillin, Pipraks,
- Penicillins - semi-synthetic drugs of the penicillin group, which are used in the treatment of urinary system inflammatory processes in the form of tablets or injectable powders, are known as Ampicillin, Penodil, Zetsil,
- cephalosporins - modern fourth-generation drugs, which have a wide spectrum of action, are presented in the pharmacy network in the form of a solution for intravenous or intramuscular administration of Cefanorm, Cepin, Cefomax,
- fluoroquinolones - third and fourth generation antibacterial drugs, which are rarely used to treat inflammation in urology, due to the high toxicity of the drug (Norfloxacin, Levofloxacin, Moxifloxacin),
- Beta-lactams are one of the most effective drugs for antimicrobial therapy, intended for intravenous administration of Meropenem, Doriprex,
- chloramphenicol - a large group of antibiotics whose active ingredient is chloramphenicol, these are drugs Nolitsin, Otomycin, Marmacetin.
From pyelonephritis can prescribe such drugs as Gentamicin, Amikacin, which give a good anti-inflammatory effect, but have a large number of side effects, including a partial or complete hearing loss. Apply in exceptional cases.
Broad-spectrum antibiotics are always prescribed by doctors with extreme caution, since they do not have a selective effect and affect all microorganisms. Choosing from the numerous list of pyelonephritis drugs, the doctor will choose an antibiotic that will meet the following requirements:
- have a minimal toxic effect on the patient’s body,
- have a pronounced antibacterial effect,
- combined with other complex treatment drugs,
- excreted mainly with urine.
Nephrologists use early and late criteria to evaluate the appropriate treatment, which include:
- decrease and normalization of body temperature,
- there are no symptoms of intoxication,
- normalization of the kidneys,
- improved clinical indications
- no pain in the kidneys and lower back.
The most informative and important criterion of a properly selected antibiotic for the treatment of pyelonephritis is the absence of recurrence of the disease during three months after an acute attack.
Recommendations for the treatment of the acute form of the disease
In the treatment of the acute form of the disease, it is necessary to know which antibiotics for this type of pyelonephritis will be most effective. The choice of drug depends on the type of pathogen:
- if the disease is caused by Escherichia coli, the aminoglycosides, fluoroquinolones and cephalosporins, which are prescribed for a 7-10-day course, will be most effective,
- in identifying such a pathogenic microorganism as Proteus, it is advisable to use Gentamicin, Nitrofuran, Ampicillin,
- when kidney exposure enterococcus is recommended to combine gentamicin with ampicillin, or vancomycin with levomycetin.
In the treatment of acute pyelonephritis, it is recommended to treat the disease in a hospital, under the close supervision of the attending physician. All antibacterial drugs are recommended to be taken parenterally, in the form of intravenous or intramuscular injections, in order to more quickly achieve a therapeutic effect.
Features of the use of antibacterial drugs
Comprehensive treatment of pyelonephritis is aimed at:
- suppression of the inflammatory process in the kidneys,
- pathogenetic effect
- prophylactic anti-relapse treatment
- immunocorrection after a course of antibiotic therapy.
To suppress the inflammatory process, Ceftriaxone is prescribed 1 g intramuscularly or intravenously, the course duration is 7-10 days. Intravenous injections of gentamicin at the rate of 3-5 mg per 1 kg of weight. In the form of tablets prescribed Augmentin 500 mg 3 times a day. Another modern and highly effective preparation for pyelonephritis that can be used for children and pregnant women is Flemoklav Solyutab. This is a semisynthetic antibiotic that meets all the requirements of the drug for antibacterial therapy. Adults appoint 625 mg 3 times a day.
After a course of antibiotic therapy, which lasts 7-10 days, it is recommended to take anti-relapse drugs. For this purpose, Biseptol, Nitroxoline or 5-NOK is prescribed. For the correction of the immune system, immunomodulatory drugs are prescribed, which must be prescribed by an immunologist. From safe means to strengthen the immune system and maintain the kidneys after antibiotics, you can drink herbal kidney tea.
All preparations for the complex treatment of pyelonephritis should be prescribed individually by the attending physician, taking into account the severity of the disease, the general health of the patient, and the type of pathogen.
With prolonged use of antibiotics may develop a number of side effects and complications:
- toxic effects on the kidneys, liver and other organs,
- dyspeptic disorders of the gastrointestinal tract,
- individual intolerance to the drug or its components,
- development of fungal infection
- complications in the form of an abscess, hematoma, phlebitis with inappropriate parenteral administration of the drug, etc.
With proper selection of the drug, treatment under the supervision of a physician and medical personnel, monitoring of clinical indicators of blood and urine, the risk of complications is minimized. At the same time, the patient has every chance of complete healing from the illness and the prevention of repeated exacerbations.
Principles of treatment
Pyelonephritis treatment regimen is prescribed by a specialist. Therapy is selected individually for each case.
New pyelonephritis pills are available almost daily, but do not always give a positive result in medical practice.
When prescribing medication, the doctor takes into account all aspects of the disease:
Properly selected drugs for the treatment of pyelonephritis facilitate the overall health of the patient and relieve symptoms. Each drug has its own contraindications, so it requires careful selection by a specialist, taking into account the health status of each patient.
How antibiotics work
Getting into the focus of inflammation, antibiotics begin to act. Their action is aimed at bacteria. Such drugs for pyelonephritis are very effective. They are minimally nephrotoxic, almost completely excreted in the urine.
What is more effective shots or pills? If pyelonephritis is in the light or medium form, then pills for treatment is the best option. The introduction of antibiotics in injections is recommended for patients with severe pathology.
When pyelonephritis is necessary to determine which antibiotics, in what dosage, according to what scheme to take. This can only be a doctor. In order to determine how to treat the disease, what drugs can cure the disease, you need to be examined.
It is important for the patient to consult a specialist and know what can be eaten with this pathology, and what should be avoided. Special diet allows you to quickly deal with the disease.
The main groups of antibiotics for the treatment of pyelonephritis
Antibiotics are required at the first stage of therapy. A wide range of pathogens requires the right choice of drugs.
Preparations for pyelonephritis must meet certain requirements:
- Does not affect the condition of the kidneys and their functionality,
- Fully excreted in the urine,
- It is a bactericidal substance.
At the first symptoms of the disease, be sure to consult a doctor. What antibiotics to take to the patient with pyelonephritis, the doctor decides on the basis of test results. Self-medication and the prescription of self medication without examination can harm health.
Consider several groups of drugs:
- Quinolones and fluoroquinolones.
More often in practice they use penicillin row - Amoxicillin, Ampicillin. At the discretion of a specialist, depending on the state of health of the patient, injection methods of drug administration are used or taken in pill according to the schedule.
In addition to antibacterial agents, other drugs are used in the complex treatment of the disease.
The treatment regimen can be supplemented by:
Antispasmodic - No-shpa relaxes the smooth muscles of the whole organism, including the organs of the urinary system. Cystone with pyelonephritis enhances the effect of antibiotics and sanitizes the kidneys and urinary tract. Diclofenac is indicated for a strong inflammatory process in the kidneys. Mydocalm strengthens the anti-inflammatory effect of diclofenac, relaxes smooth muscles. Of nonsteroidal anti-inflammatory drugs often choose Movalis.
Penicillins have the lowest toxicity of all antibiotics.
Ampicillin, Amoxiclav, Amoxicillin - penicillin group drugs have a positive effect on the dynamics of treatment.
Analogue Amoksiklava - Augmentin contains the same active ingredients. Augmentin tablets at a dosage of 625 contain amoxicillin 500 mg and clavulanic acid 125 mg. Amoxiclav 250 mg tablets are intended for children, the dosage and regimen depends on the severity of the disease. Amoxicillin in pyelonephritis is most often combined with clavulanic acid.
What are amoxicillin tablets for pyelonephritis? This drug is highly active against gram-negative bacteria and hemophilic bacilli. Has less activity against streptococci. Amoxicillin capsules better retains healing properties, as in this form the drug is stable against gastric juice. Tablets are convenient. They can be absorbed and chewed. They taste good. Amoxicillin is taken at least seven days.
Augmentin is a modern means. Augmentin tablets do not have a negative impact on the management of vehicles and other mechanisms. The dosage must be agreed with the doctor.
Amoxiclav tablets are taken strictly according to the scheme. Taking the drug is recommended during meals.
Release form Amoxiclav:
- Coated Tablets
- Powder for ingestion,
- Powder for injection.
What pills chloramphenicol? Levomycetin has various indications for use. It is used in the treatment of infections that are caused by pathogens that are sensitive to the drug. Previously, chloramphenicol was often used to treat kidney infections. Now it is written out much less frequently due to the unpredictability of the effect of the action.
Antibiotics for pyelonephritis is the basis of therapy, therefore the effectiveness and duration of the treatment process depend on their correct choice. Vilprafen Solutab tablets and Azithromycin tablets are also one of the choices. An antibacterial drug is prescribed for 3 days to monitor its effect on the human body. If a positive effect in the treatment of the disease does not occur during this period of time, then another drug is recommended for administration.
These are antibiotics with 7-aminocephalosporic acid at the base of their chemical structure.
Ceftriaxone with pyelonephritis is used for the treatment of uncomplicated and complicated forms. It prevents the development of complications, is used for injections. Injections for pyelonephritis in the acute period of the disease is much more effective than taking pills. This kidney antibiotic is considered a potent substance.
Analogues of the drug are those substances that can replace ceftriaxone. These are drugs that belong to the same group and have a similar effect. Since the drugs have a fairly large list of contraindications and side effects, the physician should deal with their selection.
In the diagnosis of pyelonephritis antibiotics are selected from different groups, obtained in different ways.
Fluoroquinolones are antibacterial agents obtained by chemical synthesis. They are able to suppress the activity of gram-positive and gram-negative microorganisms. Their discovery occurred in the middle of the last century.
Ciprofloxacin and Nolitsin are representatives of this class of antibiotics. Ciprofloxacin tablets are widely used in urological practice. Ciprofloxacin tablets at a dose of 500 mg are about twelve hours. Nolitsin with pyelonephritis is used, subject to sensitivity to the drug.
В перечень препаратов эффективных при лечении пиелонефрита входят карбапенемы.
Resistant strains of microorganisms cause certain infections. For the treatment of these types of infections choose carbapenems. Treatment with antibiotics of this class is most often carried out in the intensive care units and organ transplants. The drug is prescribed after identifying the causative agent of pathology. How to treat the disease, experts decide.
Sulfonamides are significantly inferior to antibiotics of the last generation with their activity and have high toxicity. These drugs are representatives of the oldest class of drugs. One of the medicines of this class is Biseptol. The release form of the drug - tablets of 120 and 480 mg.
When ingested, nitrofurans are well and rapidly absorbed. They are important in the treatment of acute uncomplicated forms of urinary tract infection. Representative of this class is furadonin. It is required to take it during or after meals, as it has pronounced side effects. Furazolidone enhances the effect of action in combination with other antimicrobial agents. Also from this group of drugs used furamag and furagin with pyelonephritis.
Nalidixic Acid Preparations
Nalidixic acid preparations are usually used not as medications for treatment, but as prophylactic purposes. This list includes: Negram, Nalidix, Nevigremon. Preparations in due volume accumulate in the organs of the urinary system. Medicines are sold in pharmacies in pills or capsules.
8 hydroxyquinoline derivatives
How to treat patients, which drugs to use in each case, determined after the examination. When pyelonephritis antibiotics prescribed necessarily.
The representative of this class is nitroxoline. It is usually prescribed for two to three weeks. The remedy fights bacteria of the Candida genus, selectively with gram-negative and gram-positive bacteria. It is used to prevent the exacerbation of the disease.
The drug, which is prescribed for treatment, you must take the scheme, observing the dosage.
In case of hypersensitivity to 8-hydroxyquinoline derivatives, the drug is contraindicated.
What antibiotics treat chronic pyelonephritis
Chronization of the disease contributes to the asymptomatic course of the disease at an early stage. Helps cope with the disease receiving properly selected antibiotics.
What to take in the chronic course of the disease? The main goal is to destroy the causative agent of inflammation. Antibacterial drug is selected depending on the type of microorganism that caused the disease. Usually used 2nd generation cephalosporins and protected penicillins.
Treatment for acute pyelonephritis
Treatment of acute pyelonephritis should begin with antibiotics. Note that drug treatment in adults differs in dosage and regimen from the treatment of children.
The choice of treatment for the acute stage of pyelonephritis depends on the results obtained by seeding. The test, which allows to evaluate the sensitivity of the flora, makes it possible to make a choice of the drug. In the acute phase of the disease, antimicrobial drug therapy begins in the form of injections.
Mild forms of pyelonephritis can be treated with sulfonamides. If after two or three days the clinical effect is not achieved, the drugs are replaced with levomycetin or penicillin. Levomycetin is part of the levomycetin tablet. Preparations from the penicillin group are selected on the basis of the specific situation: the required dosage and form of administration.
Antibiotics prescribed for women during pregnancy
In gynecology, antimicrobials are used for a wide range of diseases.
Pyelonephritis is common in women during pregnancy, and the doctor decides which antibiotics to take.
Antibiotics of the fluoroquinolone group are not prescribed at all during gestation. In very rare cases, monural is prescribed for pyelonephritis, as it has quite a few contraindications especially during pregnancy. The effects of taking the combined herbal preparation - urolesan have not been studied.
Penicillin is officially approved during pregnancy. Drugs do not pose a danger to the fetus.
For treatment during this period, Kanephron is successfully used for pyelonephritis, since it contains only herbal ingredients. How much to drink Kanefron, in each case, sets the therapist and nephrologist. A preparation with a natural composition - Fitolysin for pyelonephritis is often used to solve this problem during pregnancy.
Which antibiotic is better to use in children
Antibiotic treatment of children is not always welcome, but it is necessary.
The body of the child is very sensitive to toxic drugs, so the selection of funds is carried out with this account.
Antibiotics for pyelonephritis in children are represented by a relatively small assortment:
- Penicillins - Augmentin and Amoxiclav. In addition to the usual pills, these antibiotics are available in the form of a sweet suspension for young children.
- Cephalosporin group - Cefotaxime, Cefuroxime, Ceftriaxone. They most often are only in injections. As well as Cedex, Supraks, existing in the form of suspensions, capsules and soluble tablets.
- Aminoglycosides - Sumamed and Gentamicin and carbapenems in rare cases also have a place to be, but they are most often used as an alternative option and as part of combination therapy.
Sumamed 500 mg dispersible tablets and capsules are prescribed for children over the age of twelve. Six-month-old children and older than Sumamed are prescribed in the form of a suspension, children over three years old are prescribed in the form of tablets 125 mg, dosing taking into account the body weight of the child. This tool and any other antibiotic can be taken only as prescribed by a doctor.
How to understand that antibacterial drugs act
Antibiotics have a wide spectrum of action. The main principle of antibiotic therapy is to make the right decision on the prescription of an antibacterial drug in accordance with the sensitivity of the pathogen. Usually on the second day of taking the pills, the state of health becomes better, and the temperature returns to normal. If this does not occur, then either the wrong drug is chosen or the dose is not sufficient.
Rules for the appointment of antibiotics for pyelonephritis
Preference is always given to broad-spectrum antibacterial drugs for internal use in the case of uncomplicated disease.
The duration of treatment with them usually lasts about 2 weeks, although the symptoms of the pathology disappear earlier.
After this period, there are already antibiogram results on the hands, so if the use of the drug did not bring a positive effect, further treatment is carried out purposefully, taking into account the sensitivity of the microorganism to the drug.
In classical cases, the symptoms of the pathology disappear after 5-7 days, but their absence does not indicate a complete deliverance from the pathogen, therefore, a patient who has been diagnosed with pyelonephritis for the first time needs anti-relapse treatment for a period of 1-2 years.
If antibiotics are prescribed for more than 2 weeks, antifungal agents and probiotics should be added to them (to restore the normal microbial environment of the intestine).
Antibiotics for cystitis and pyelonephritis: how to determine effective and reliable
To completely get rid of bacteria that cause inflammation in the urinary organs of men and women, do not do without antibacterial agents.
Antibiotics for pyelonephritis and cystitis is the basis of therapy, which can be supplemented by other means acting as an auxiliary treatment.
Why is it so difficult to manage without antibiotics, and what kinds of them can be a salvation for the patient?
Why do we need antibiotics?
Pyelonephritis and cystitis are diseases that have long been known to mankind. It can be caused by different types of organisms - viruses, bacteria or fungi. In the overwhelming majority of cases, the causative agent of the disease is precisely bacterial bacillus, and therefore it is very likely that we can speak of bacterial cystitis.
A fungal infection can also cause the development of inflammation, but it usually occurs against a background of reduced immunity. Finally, the penetration of viruses into the organs of urination is possible only with unprotected sexual contact from a partner who is himself a carrier of the infection.
In this case, most often we are talking about a sexually transmitted disease, and cystitis is only its complication or consequence.
What antibiotics are taken for cystitis and pyelonephritis
To list all types of antibacterial agents is quite a long and tedious task. Most often, doctors are repelled by a group of antibiotics that are recommended for use by the patient in this situation. The list here is as follows:
- penicillin products,
- phosphonic acid.
It is highly desirable, before prescribing an antibacterial agent, to analyze the sensitivity of bacteria that caused the inflammation to each group of drugs. This will allow the patient to save his money, time and health, because the choice of the urologist "at random" is not always correct.
If the doctor does not offer an analysis, you can insist on such a preliminary diagnosis or change the doctor to a more qualified urologist.
These are very powerful antibacterial agents that are very often used to treat cystitis and pyelonephritis. Among the most famous names of this group can be remembered Ciprofloxacin and Nolitsin.
Nolitsin will help when the inflammation has passed into the chronic stage, and the patient has already experienced a lot of drugs. The disadvantages of antibacterial agents from this group include an impressive list of possible side effects, and therefore the doctor must be sure that the patient does not have contraindications and serious associated diseases.
What antibiotics to use for pyelonephritis?
When diagnosing an infectious disease, antibiotics are used that are able to cope with pathogenic bacteria in the human body. The kidneys clean the blood from toxins, accumulate liquid in the pelvis, and then remove it through the urinary system. Therefore, antibiotics for pyelonephritis should have the least possible toxic effect and be easily removed from the body.
- Antibiotic treatment
- Types of antibiotics
- Women and children
Dangerous bacteria that have fallen into the kidney, begin to take an active position, gradually multiplying, thereby causing the body to respond with a defensive response - the immune system triggers antigens to fight infection. Active development of leukocytes begins, which destroy not only harmful microorganisms, but also kidney cells.
Before prescribing a course of treatment, the doctor must identify the pathogen that caused the inflammatory reaction in the kidneys and find out the level of white blood cells.
This is due to the fact that any type of antibiotic has a targeted action in the fight against a particular microorganism and in this case will be more effective.
If it is impossible to classify a harmful bacterium by means of tests, broad-spectrum antibiotics are used.
After the start of medication, the improvement comes after a week, the symptoms gradually disappear. Pyelonephritis can be diagnosed in two types:
- acute stage proceeds with pronounced symptoms,
- chronic stage implies more diffuse symptoms, occurs in the long-term absence of treatment for the acute stage of pyelonephritis.
Types of antibiotics
The basic requirements for antibiotics are:
- fairly high concentration in the urine,
- no toxic effects on the kidneys,
- susceptibility of pathogenic bacteria to prescribed drugs.
After 2-3 days, the patient undergoes repeated tests to determine the positive dynamics, in the absence of such, they refuse to take the prescribed antibiotic and replace it with a more effective one. Preparations are prescribed depending on the form of the disease: acute or chronic.
In the acute form of the disease is used:
Causes of pyelonephritis
The disease can infect a person of any age, although they are ill most of all:
- small children - due to the anatomical features of their development,
- women aged 18 to 30 years: they have the appearance of pyelonephritis is directly related to the onset of sexual activity, childbirth or pregnancy,
- retired men because of their propensity to develop prostate adenoma.
In addition, the development of the disease is promoted by the following factors: low immunity, elevated blood sugar levels, chronic inflammatory diseases, and frequent hypothermia.
Signs of pyelonephritis
The acute form of the disease often begins unexpectedly. In the urine increases the protein, red blood cells and pus. The main symptoms of this disease are:
- high temperature (up to 40 ° С),
- heavy sweating
- vomiting and nausea
- pain in the lower back.
In acute bilateral pyelonephritis, symptoms of renal failure are often found. The disease can also be complicated by the development of paranephritis and the formation of ulcers in the kidneys.
Chronic pyelonephritis sometimes arises from previously transferred acute form, which is not cured until the end. The disease is usually noticed when urine is examined, or when blood pressure is measured.
Signs of chronic pyelonephritis are not as pronounced as in complex forms. The most common of these symptoms are:
- feeling of weakness and headache
- decrease or lack of appetite
- frequent urination,
- pale dry skin.
How to cure pyelonephritis
According to urine tests, doctors determine the presence of intestinal bacteria in the body, and it also turns out that the indicators of proteins and leukocytes in the blood have increased.
Diagnosis helps to identify previously transferred acute purulent inflammation and the presence of chronic diseases. The x-ray pictures of the doctors pay special attention to the examination of the kidneys and their size.
Features of the use of antibiotics for pyelonephritis
Pyelonephritis is one of the most common diseases of the kidneys that are referred to a doctor. This disease causes pathogenic microflora, which enters the patient from the bladder or with the blood flow.
It is for this reason that a highly qualified doctor who will individually prescribe the most effective and safe antibiotics for pyelonephritis should deal with the treatment of the disease.
In the absence of adequate therapy, pyelonephritis can have adverse consequences for the patient’s later life.
Antibiotics for pyelonephritis: how to treat kidney inflammation in women and men, data on the latest generation of drugs
When a diagnosis of pyelonephritis (inflammation of the kidneys) is established, the attending physician usually prescribes antibiotics, since the main cause of the disease is the presence of an infection in the patient’s body, which must be eliminated.
Preparations for the treatment of pyelonephritis currently exist in mass, but all of them must have bactericidal properties of a broad spectrum of activity, minimal toxicity and be excreted from the body in a natural way along with urine.
Antibiotics for pyelonephritis: what is the best treatment for women and men
The antibiotics most commonly used for kidney inflammation include:
- Aminopenicillins: amoxicillin, penicillin, which is highly active against enterococci and Escherichia coli. The main disadvantage of them is their susceptibility to the action of the main enzymes produced by the majority of pathogens of pyelonephritis. Penicillin is often prescribed to treat kidney inflammation in pregnant women. In other cases, the use of such drugs is considered impractical.
- The Flemoklav Solutab tablets belong to the group of semi-synthetic antibiotics, the effectiveness of their constituent amoxicillin and clavulanic acid has been confirmed by long-term clinical studies. The drug has great activity against gram-positive and gram-negative microorganisms, can be used by women during pregnancy and children from 3 months. Side effects are extremely rare, these include the occurrence of skin rash, angioedema, leukopenia. Analogs: amoxiclav, augmentin and other drugs of this series.
- Cephalosporin antibiotics belong to the group of low-toxic semi-synthetic and natural preparations. The basis of the group is a special acid 7-ACC, with timely treatment preventing the transition of acute pyelonephritis to the purulent form of the disease. The main representatives of this group of drugs (and there are more than 40 of them) are: cefalexin, cefalotin, zinnat, claforan, tamycin, ceftriaxone (third generation). In most patients, general improvements are observed from the third day of use.
- Aminoglycosides are used to treat a complicated form of kidney inflammation. Мощное бактерицидное воздействие на болезнетворные бактерии (в том числе синегнойную палочку) оказывают такие средства, как амикацин, гентамицин, нетилмицин. Основной недостаток использования аминогликозидов заключается в их нефротоксичности.Among the side effects are: hearing loss, the development of reversible renal failure. Drugs in this group cannot be prescribed to people of old age, as well as with repeated treatment with an interval of less than a year.
- Fluoroquinolones of the first generation: ciprofloxacin, ofloxacin are used to treat the acute form of the disease. These drugs have low toxicity, which allows taking them up to two times a day, and is well tolerated by patients of all ages: both adults and children. Second-generation fluoroquinolones: moxifloxacin, lomefloxacin, levofloxacin, which are active against pneumococci, are often used to treat the chronic form of the disease during exacerbations. Contraindications to the use of intolerance to the individual components of the drug, pregnancy and breastfeeding. The side effects of this group of drugs include: diarrhea, nausea, flatulence, dizziness, the development of genital candidiasis, urticaria.
- Beta-lactamate antibiotics of the carbapenem subgroup (last generation antibiotics). Used in injections. Excreted by the kidneys in unchanged form. Therefore, with extreme caution, drugs of this type are prescribed in the treatment of pyelonephritis to persons suffering from renal failure. The most commonly prescribed drugs are: meropenem, doriprex, jenem.
The choice of a particular drug depends on the type of microorganism that caused the disease, and its sensitivity to antibacterial drugs. The dosage of the medicinal product is selected individually, taking into account the state of the patient's kidney function. Antibiotic treatment is preceded by a series of tests, an ultrasound procedure and a computer tomography.
Material updated 04/24/2017
Antibiotics for pyelonephritis: the need or prevention of complications?
In order for the treatment of any disease to be effective, you should consider the causes of its occurrence. If you ignore this requirement, the therapy may not give any results. That is why the treatment of pyelonephritis always includes an individually selected course of antibiotics. Only these drugs can affect the pathogen and eliminate the main cause of inflammation.
Why antibiotics or who is to blame for the disease?
Pyelonephritis is an inflammation of the kidneys involving cups and pelvis in the pathological process. The cause of the disease is always infection: streptococci, E. coli, enterobacteria, and so on.
The pathogen can enter the kidneys through the bloodstream from distant sources of infection, as well as in an ascending pathway in the presence of pathologies such as colpitis, cystitis, urethritis and others. The right kidney is most often affected, which is explained by anatomical features.
There is a disease in women, men, as well as in children, including infants, and in the latter, kidney pyelonephritis can cause particularly dangerous complications. Therefore, when the first signs appear, it is necessary to select a course of treatment.
The disease may be acute, subacute and chronic. The clinic is usually bright and includes symptoms such as fever, back pain, dysuric disorders, malaise and other signs of intoxication.
In addition, pathology can be combined with other diseases, which slightly changes the clinic. Thus, pyelonephritis with stones can occur in severe pain and a sharp reduction in urine output as a result of the blockage of the ureter.
Left untreated, this can lead to kidney failure and wrinkling of the kidney. To prevent this and achieve a stable remission, it is important to completely eliminate the cause of the pathology.
Broad-spectrum antibiotics do an excellent job with this task, but it is still better to use a drug whose effect is directed to a specific group.
In order to choose the right antibiotics for the treatment of pyelonephritis, first of all you need to make a diagnosis that reflects the causes, that is, the existing pathogen.
This may be viral, fungal or bacterial pyelonephritis. For this purpose, an analysis of urine sediment.
In addition, when conducting this study, the sensitivity to the drug to be used in the treatment of pyelonephritis is necessarily determined.
Features of antibiotic therapy
As already mentioned, the choice of the drug depends on the pathogen. Also important is the severity of the condition. Therefore, it is necessary to evaluate all the possible nuances and only after that to select antibiotics for pyelonephritis and cystitis. With a mild degree of inflammation can be limited to pill medications, but a heavy degree requires the appointment of injections and even intravenous fluids.
The most commonly used groups of antibiotics are:
- Preparations of aminopenicillin group. These include Penicillin, Amoxiclav, Amoxicillin and others. They are effective against enterococci and Escherichia coli. Such antibiotic therapy can be used during pregnancy.
- Cephalosporin antibiotics are prescribed in cases where there is a risk of complications of the pathology by a purulent process. These include Digran, Cefalotin, Cefalexin, Ceforal, Suprax, Tamycin, Tsiprolet, Klaforan and others. These drugs are of low toxicity, but at the same time, already 3-4 days after the start of administration, a significant improvement is noted.
- In the complicated form, aminoglycosides are used - Gentamicin, Amikacin or Netilmicin. But it should be remembered that these antibiotics for pyelonephritis can have a nephrotoxic effect. Accordingly, they are not recommended for use in the treatment of people older than 50 years, as well as in patients who have already been prescribed these drugs in the last year.
- Fluoroquinols of the last generation are especially popular. This is, first of all, Moxifloxacin, Levofloxacin and Nolitsin. Such tools are very often used in complicated course, as well as in chronic forms.
- Macrolite preparations can also be used in the treatment of diseases such as inflammation of the kidneys. The most commonly used are Wilprafen and Sumamed. They are effective against a large number of gram-positive and gram-negative bacteria. Appointed, as a rule, after reaching the age of 14 by children.
In addition to the above, in some cases, chloramphenicol may be prescribed, although it is more often used in children. Also, when diseases are moderate, uroseptics are prescribed, in particular, Furadonin, Furagin or Furamag.
Especially often physicians and pediatricians treat pyelonephritis with Biseptolum.
Of course, this tool has a large number of contraindications and side effects, but at the same time, if you take Biseptol according to a certain scheme, without exceeding the dosage, you can minimize all negative aspects of the drug.
There is still a huge amount of drugs used in the treatment of inflammation of the kidneys. You can drink Monural, Prick Ceftriaxone, use other drugs drip. But you can not do it yourself. After treatment with an antibiotic, if it is ineffective against the available flora, resistance to the drugs of this series is formed.
Only a doctor after a thorough examination and a full examination will be able to find a cure for pyelonephritis, which will be effective in your case.
You can only use natural products such as Fitolysin, Canephron from cystitis and pyelonephritis, as well as use the products of NNPTSTO and so on. Especially it should be noted that the treatment with Canefron favorably affects the action of antibiotics, as it is able to strengthen it.
But besides this, pyelonephritis is treated by other means, the action of which can be aimed at improving urine outflow, lowering the temperature and so on.
Normalization of urine outflow
As a rule, the treatment regimen is always supplemented with means that improve the flow of urine from the pelvis. It can be difficult with stones, narrowing of the ureters, congenital abnormalities against the background of a neurogenic bladder and prostate adenoma. It should be remembered that treatment with antibiotics without addressing this cause will only achieve a temporary effect.
The choice of method depends on what exactly violates the flow of urine. Often used surgery. At the same time, in acute pyelonephritis in the first place, improvement should be achieved. For this purpose, the pelvis puncture is often performed, after which the condition improves dramatically.
Anti-inflammatory therapy for pathology
In order for an antibiotic with pyelonephritis to quickly reach the source of infection, it is necessary to use anti-inflammatory drugs in parallel. In addition, they are also able to reduce fever, eliminate pain and reduce tissue swelling. As a result, the temperature after the injection decreases, and the pain decreases.
Normalization of the blood supply to the kidneys
In order for the kidney tissue to recover as quickly as possible, you should use the means to normalize the blood supply. The fact that kidney disease is accompanied by a violation of the distribution of blood through the vessels of the body. As a result, the blood stagnates in the veins and tissues receive less oxygen. In that case, if you do not treat this condition, there may be areas of necrosis.
Such drugs can reduce the adhesion of platelets and improve the elasticity of red blood cells.
As a result, the blood moves more freely through the vessels, oxygen supply improves, edema decreases, and so, to some extent, the drug has an anti-edema and analgesic effect.
It should also be noted that the selected antibiotic is delivered to the kidney with blood flow, therefore, due to this it quickly acts on the microorganism in the kidney. These tools are especially needed after a kidney stroke and in case of suspicion of wrinkling and renal failure.
Making the kidneys work
Recently, doctors use the following tactics. Within a few days you need to take diuretics. Next, make the abolition of the kidneys to rest. As a result, the work of all glomeruli is activated.
In addition, if at the same time drinking pills with antibacterial properties, the delivery of active substances to the inflammatory area will take place much faster due to improved blood flow.
Also, this technique allows to improve the excretion of urine.
With the selected tactics can be used various drugs from NNPTSTO, decoctions of herbs, tinctures, medicines and so on. The duration of admission and rest periods is selected individually.
Features of treatment of pyelonephritis
The methods of treating kidneys are described in the video:
Given that the list of antibiotics is incredibly huge, you do not need to rush from one drug to another. As a rule, during a consultation or hospital stay, doctors explain on which day the selected drugs are working.
If the pain does not go away after a few days, and the temperature also holds, the treatment regimen should be reviewed, as this indicates its inefficiency.
As a rule, this is a repeated analysis of urine for bacterioscopic examination of the sediment and the determination of the pathogen and its sensitivity, which allows you to more accurately decide how to treat pyelonephritis in this situation.
It should also be noted that antibiotics should be taken during the period indicated by the doctor. Even if the symptoms of pathology are gone, no need to abandon the drug. As a result, the microorganisms will become more resilient.
In other words, to cure kidney inflammation, you need to complete a full course. The same goes for the name of the antibiotic. If an analogue was recommended to you at the pharmacy, you should not immediately agree, since even very similar means may have different side effects and contraindications.
Therefore, you should purchase the drug, the name of which is indicated by the specialist.
Thus, it can be concluded that in case of inflammation of the kidneys various treatment can be applied: pills, injections, herbs, spa treatment, diet therapy. It is important to know how much to drink this or that drug.
After you have punctured or drank it, you need to re-take tests to assess the effectiveness. If the results are bad, you should check with your doctor how to treat the kidneys in the future and which drugs to use.
But, as already mentioned, the new course always begins after bacterioscopic analysis.
You do not need to think alone whether pyelonephritis is curable. It is enough to consult a specialist and be examined. Based on this, he will provide you with a list of funds needed for treatment. In addition, remember that the care and treatment of the patient is also particularly important, which will reduce the risk of various complications.
What antibiotics are prescribed for pyelonephritis?
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It is known that the cause of the inflammatory process in the kidneys are most often bacteria. To combat them used drugs of various kinds. When choosing antibiotics used to treat pyelonephritis, whatever good reviews they may collect, you should always consult with your doctor.
Typical symptoms of pyelonephritis:
- Abdominal pain,
- kidney pain,
- increased body temperature
- nausea and vomiting,
- change urine type
To understand what antibiotics to drink with pyelonephritis, it is necessary to find out the response of pathogenic microflora to the antimicrobial effect of the drug. Different drugs do not equally effectively affect various pathogens of kidney tissue inflammation.
For example, staphylococcus does not respond to penicillins because it actively secretes penicillinase, protecting itself from the action of the antibiotic. Other bacteria - enterococci - are resistant to the effects of cephalosporins, despite the fact that these are antibiotics for pyelonephritis with a wide spectrum of action.
Thus, the doctor can carry out the appointment of a drug only after the results of all necessary tests, namely:
Bacteriological seeding can reliably determine the response of microflora to the influence of various antibiotics. Using this method, find out what in the urine there are pathogens and in what quantity. This allows you to most accurately determine the type of drug, dosage and course of administration.
Antibiotics for the last generation of kidney pyelonephritis
The goal of treating acute or chronic pyelonephritis is to eliminate the inflammatory process. When prescribing an antibiotic, it is important to determine the type of pathogen, so it is unacceptable to take such drugs yourself.
For the treatment of pyelonephritis, penicillins (Ampicillin, Amoxicillin, etc.) can be prescribed, which are effective against enterococci, proteins, and E. coli.
However, this group of antibiotics has a serious drawback - drugs can lose their medicinal properties under the action of enzymes produced by individual bacteria. Such drugs are mainly prescribed for the treatment of pyelonephritis during pregnancy.
An exception is the modified form of the antibiotic amoxicillin - Flemoklav Solyutab. It contains clavulanic acid, which reduces the adaptability of bacteria to the drug.
Most often, pyelonephritis is prescribed antibiotics of the cephalosporin group, which are divided into 4 generations. The first includes: "Cefradin", "Cefazolin", "Cefalexin". They show an active action against gram-positive microorganisms, including those resistant to penicillins.
These drugs are not prescribed for the acute form of the disease. The second-generation drugs include Ceforuksim, which is used only in the treatment of chronic processes. The third generation drugs include: Cefixime, Ceftriaxone, Ceftibuten.
They are effective in the treatment of complex forms of pyelonephritis, have an active effect against Pseudomonas aeruginosa.
The fourth generation of antibiotics of this group, to which Cefepim belongs, possesses all the positive qualities of predecessors, as well as a directed effect against gram-positive and gram-negative forms of pathogens.
One of the most modern drugs are fluoroquinolone antibiotics: Ciprofloxacin, Pefloxacin, Ofloxacin. These drugs are effective against almost all pathogens of pyelonephritis and have minimal nephrotoxicity.
The second-generation fluoroquinolones include: Moxifloxacin, Lomefloxacin, Sparfloxacin, Ciprofloxacin, Norfloxacin. Fluoroquinolone antibiotics are contraindicated during pregnancy and lactation, as well as children under 16 years of age.
Antibiotics aminoglycosides ("Gentamicin", "Tobramycin", "Amikatsin") should be used strictly under medical supervision, because they have a powerful antibacterial effect and have high nephrotoxicity. These drugs are contraindicated in the elderly.
Antibiotics for kidney pyelonephritis: treatment guidelines
Лечение пиелонефрита антибиотиками является самым эффективным методом. При воспаление почек, не стоит экспериментировать и прибегать к народной медицине или другим неоднозначным методам. Doctors have long found the most effective way to combat pyelonephritis and this is the right course of antibiotics.
Very often, this disease appears as a result of cystitis and is accompanied by the following symptoms:
- high temperature
- kidney pain (lower back)
- general weakness
- high sweating
- transferred cystitis.
In this article we will tell you what antibiotics should be used in different situations, what result should be expected after a certain period of time and how to properly cure pyelonephritis.
- This group of antibiotics is used in extremely severe cases.
- They have an ultra-wide spectrum of exposure, resistance to beta-lactamase, special enzymes of bacteria.
- They are used for blood infection, pyelonephritis, caused by several pathogens at once, with the ineffectiveness of previously prescribed treatment.
- Do not work in relation to chlamydial flora, methicillium-resistant staphylococci.
The antibacterial agent of the oxyquinoline group, another name for this series of antibiotics, is nitroxoline.
- Destroys some bacteria of the genus Candida, gram-negative and gram-positive bacteria selectively.
- It, as well as nitrofurans, is used to prevent exacerbations.
- Prescribe the drug nitroxoline (5-NOK) course for 2-3 weeks.
Effective antibiotics for pyelonephritis
One of the most common kidney diseases is pyelonephritis. This is an inflammation of the kidneys that is caused by bacteria. Most often, children of 7-9 years old are ill with pyelonephritis, girls and women who are sexually active.
In children, the disease is caused by the need to adapt your urinary apparatus to new conditions (ie, to school), as well as by the specifics of the anatomical structure.
Men with prostate adenoma also suffer from the disease.
Symptoms of pyelonephritis
The standard symptoms of pyelonephritis are headache, temperature 38-39, chills, muscle pain, aching back pain, heartburn, pale skin. If these symptoms manifest, you should immediately contact your doctor, who will conduct tests and prescribe the correct course of treatment.
Pyelonephritis in a mild form is usually treated at home. The patient is prescribed a diet, bed rest and taking antibacterial drugs in pills or injections.
Complicated forms of the disease can create huge problems, for example, in acute forms of pyelonephritis, the temperature rises to 40 degrees and chills appear, muscle pain and vomiting are also characteristic.
Symptoms are similar to diseases such as appendicitis, cholecystitis and others, so it is very important to correctly diagnose the disease.
Antibiotics for pyelonephritis are aimed at inhibiting or increasing the activity of microorganisms, that is, they blunt or stimulate the development of bacteria.
In pyelonephritis, the doctor prescribes antibiotics in pills or injections that have no toxic effect and do not harm the kidneys. Identify the causative agent of pyelonephritis is not easy.
For this you need to conduct a series of tests that show the state of the kidneys and their functional ability, as well as the efficiency of the urinary tract.
Before starting treatment, a specialist is obliged to conduct an examination in which he will identify the causative agent of the disease. Bacteriological examination of urine is required. Although it does not give a big guarantee for the identification of a microorganism, it will help in finding the cause of the disease. Chronic or acute form of pyelonephritis depends on the method of treatment.
Taking antibiotics in pills or injections, as well as rehabilitation after treatment is also different. Treatment of the acute form of pyelonephritis should lead to the normalization of urine outflow and the self-excretion of microbes from the body.
Another important factor in the treatment of chronic disease is the prevention of exacerbations in the future. In 90% of cases, the causative agent of the disease is Escherichia coli, so treatment with antibacterial agents should be aimed at combating it.
After testing, the doctor prescribes antibiotic treatment. Most often, 4 groups of antibiotics are distinguished. They are highly effective and non-toxic for the patient.
This is Penicillin and Amoxicillin. They have excellent tolerability and are even prescribed to pregnant women, inhibits the action of bacteria, but with prolonged use, symptoms such as nausea, vomiting, loss of appetite, and dizziness may occur. As a rule, these symptoms stop after completion of the course. Still possible skin inflammation and itching.
Aminoglycoside antibacterial drugs
They are very nephrotoxic and possess strong antimicrobial properties. Most often, when they are received, hearing deteriorates, so they are not prescribed to older people. Increased thirst and a decrease in urine excretion are also observed.
Pregnant women are discharged with caution, since the drug easily passes through the placenta and can adversely affect the fetus.
It is allowed to take these drugs no more than once a year, but the effectiveness of this type of antibiotic is very high.
To date, the most commonly used fluoroquinolone group of drugs. They are low toxic and do not cause complications, as well as well tolerated by patients.
However, the drug is prohibited to children under 18 years old as the substances in it affect the periosteum and perichondrium, which promotes the growth and development of bones.
This means that the drug will slow the growth of the tubular bones of the skeleton.
Drugs in this group should not be taken with mild forms of infection. Norfloxacin is more commonly used in the treatment of cystitis, since it is more difficult for it than for other drugs to penetrate the tissues. Mild forms of pyelonephritis are treated with the following drugs:
These drugs inhibit bacteria, are well absorbed by the intestines and are easily excreted.
Pregnant women contraindicated treatment with chloramphenicol. This extensive antibiotic is aimed at the destruction of harmful bacteria, is also used in viral diseases. Contraindicated in people suffering from any blood diseases, as well as prohibited for those who have impaired liver function.
Mandatory criteria for taking antibiotics
Antibiotics for pyelonephritis are appointed only after testing, which will reveal the type of microbe and its sensitivity to antibiotics. The dosage is also selected individually.
This takes into account the state of the organism as a whole, and, most importantly, the kidneys. There are a huge number of drugs that can cure pyelonephritis in the early and late stages.
Remember: as soon as symptoms of pyelonephritis are found, it is necessary to immediately make an appointment with a doctor. Self-medication may worsen the condition.
The use of antibiotics for pyelonephritis
Pyelonephritis is the most dangerous disease characterized by the localization of the inflammatory process in the kidneys (parenchyma, that is, functional tissue, cups and pelvis of the main organs of the urinary system).
According to statistical information, every year in the medical institutions of our country more than a million cases of patients with acute type of illness are registered, about 300 thousand people are hospitalized in the hospital.
Antibiotics for pyelonephritis - the basis of the treatment of the disease. Without adequate therapy, the course of the disease can exacerbate associated infections that cause various kinds of complications (the most severe of them is sepsis). Medical data are inexorable: the mortality of patients from purulent pyelonephritis, which provoked the development of blood poisoning, occurs in more than 40% of cases.
Antibiotics for pyelonephritis: which drug to choose
Referring to the statistics, we can say that pyelonephritis, an inflammation of the kidneys, caused by bacteria, is now widespread.
Children of a school age group, at the age of 7-8 years are subject to this disease, most often. This is due to the peculiar anatomical structure of their urinary system, as well as the need to adapt to school.
Predisposed to him and the girls, women of the age of active sex life. Suffer from the disease and the men of the older age group, especially with prostate adenoma.
The clinical picture unfolds with an emerging headache, aching muscles, elevated body temperature to 38–39 degrees for a short period of time, accompanied by chills.
If you have these symptoms, you should urgently contact the nearest clinic for examination, where the doctor will select and prescribe the appropriate treatment program, or call a specialist in the house, in order not to cause complications of pyelonephritis.
Treatment of pyelonephritis of the kidneys is carried out in a hospital, in which bed rest, abundant drinking, diet and antibiotics (antibacterial drugs) are recommended. How to treat pyelonephritis with antibiotics?
Why are antibiotics effective against pyelonephritis?
Antibiotics are drugs (of natural or semi-synthetic origin) that can dull or affect the growth or death of certain microorganisms. When pyelonephritis most often prescribed antibiotics in pills. Moreover, the main requirements for antibacterial drugs in the treatment of pyelonephritis should be the presence of:
- high concentration in urine,
- they should not have a toxic effect on the kidneys of the patient.
Which antibiotic is better to take with pyelonephritis? To answer this question, you need to conduct a survey in which
- to identify the causative agent of pyelonephritis,
- determine the condition and function of the kidneys,
- determine the state of urine outflow.
With the occurrence and development of pyelonephritis, the main role is played by bacteria (microorganisms), affecting mainly the kidney tissue, its pelvis and calyx;
Antibiotics for kidney pyelonephritis: what to treat after a generation in women, a list of drugs
Pyelonephritis is a very insidious kidney disease that can occur in both adults and young children. It is dangerous in that it is often asymptomatic, which is why the patient is unaware of the presence of the disease.
Meanwhile, pathology gradually flows into the chronic form, which is very difficult to fight.
However, modern medicine does not stand still, and today there are a lot of medicines with which you can get rid of kidney pyelonephritis as soon as possible.
Antibiotic groups and their features
For the treatment of pyelonephritis in adults and young patients, regardless of the form of the disease (acute or chronic), antibacterial drugs are most often used.
However, it is not recommended to take them without a doctor's prescription - almost all antibiotics can cause serious side effects if they were chosen or applied incorrectly.
In addition, antimicrobial drugs are classified into groups, and which of them will be effective in each case, can be found only after the bakposeva.
We recommend! For the treatment of pyelonephritis and other kidney diseases, our readers successfully use the method of Elena Malysheva. Having carefully studied this method, we decided to offer it to your attention.
Often, these antibiotic groups are prescribed to treat pyelonephritis in children and adults, such as:
- Aminopenicillins: Amoxicillin, Penicillin. Due to its easy tolerance, treatment with antibiotics of this group is allowed even for pregnant women.
- Cephalosporins: Cefaclor, Cefalexin. Such antibacterial drugs rarely cause side effects, since the degree of their toxicity is very low. In this case, the patient may undergo a 2-week course of antibiotic therapy for pyelonephritis, without fear of the development of intestinal dysbiosis or other side effects.
- Aminoglycosides: Amikacin, Gentamicin. This group of antimicrobial drugs can cause serious abnormalities, in particular hearing impairment and kidney problems. Therefore, they are never prescribed to elderly patients. However, these drugs are very toxic and require strict adherence to the intervals between doses. The interval between therapeutic courses is usually 1 year.
- Fluoroquinolones - Levofloxacin, Ofloxacin. Appointed in the treatment of pyelonephritis, occurring in the acute form. They are usually used in the form of intramuscular injections. They have a number of contraindications, therefore it is forbidden to independently treat with antibiotics of this group, especially if children who are under 16 years of age are ill.
It is aimed at the speedy recovery of the body after the disease, as well as reduce the negative effect of the antibacterial drug on the intestines.
To do this, try to avoid hypothermia, eliminate from the diet all the heavy and harmful foods, coffee and strong tea. Thus, it is possible to significantly reduce the negative load on the stomach and liver, which will help these bodies to more easily transfer the influence of active substances that are part of an antibiotic.