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Contraceptive pills Yarin - instructions for use, analogues, price, reviews

Yarin tablets contain 3 mg drospirenone and 30 mcg ethinyl estradiol.

Additional substances: titanium dioxide, corn starch, talc, lactose monohydrate, magnesium stearate, hypromellose, macrogol 6000, povidone K25, pregelatinized starch, iron oxide.

How does Yarin act?

Yarin is a combined remedy, as it contains two sex hormones - estrogen and gestagen. In addition, the drug is low-dose (low doses of hormones) and monophasic (all tablets contain the same amount of hormones).

The ability of Yarina to protect against pregnancy is based on two mechanisms - the suppression of ovulation (maturation of the egg) and the change in the properties of the secret (mucus) located in the cervix of the uterus. The thick mucus of the cervix becomes an obstacle to the penetration of sperm.

In addition, taking Yarina contributes to the establishment of the menstrual cycle (with its irregularity). Pain decreases during menstruation, bleeding becomes less intense (this fact reduces the risk of developing iron deficiency anemia).

Other beneficial effects of Yarina are anti-mineralocorticoid and anti-androgen effects. This action has the hormone drospirenone - it reduces fluid retention in the body, reduces swelling, so that body weight does not increase. Antiandrogenic effect is the ability of the drug to reduce the symptoms of acne (acne) and regulate the production of fat by the skin and hair (reduces the effects of seborrhea).

Pharmacodynamics

Yarin ® is a low-dose monophasic oral combined estrogen-progestin contraceptive drug.

The contraceptive effect of Yarina ® is mainly carried out by suppressing ovulation and increasing the viscosity of cervical mucus.

The incidence of venous thromboembolism (VTE) in women with or without risk of VTE, using ethinyl estradiol / drospirenone-containing oral contraceptives in a dose of 0.03 mg / 3 mg, is the same as in women using levonorgestral-containing combined oral contraceptives or other combined peroral contraceptives or other combined perorant combination pills. . This was confirmed in a prospective, controlled, database study that compared women using oral contraceptives at a dose of 0.03 mg ethinyl estradiol / 3 mg drospirenone with women using other combined oral contraceptives. Data analysis revealed the same risk of VTE among the sample.

In women taking combined oral contraceptives, the menstrual cycle becomes more regular, painful menstrual bleeding is less common, the intensity and duration of bleeding decrease, resulting in a reduced risk of iron deficiency anemia. There is also evidence of a reduction in the risk of endometrial and ovarian cancer.

Drospirenone, contained in Yarin ®, has anti-mineralocorticoid action and is able to prevent an increase in body weight and the appearance of other symptoms (for example, edema) associated with estrogen-dependent fluid retention. Drospirenone also has antiandrogenic activity and helps reduce acne (acne), oily skin and hair. This effect of drospirenone is similar to the action of natural progesterone, produced by the female body. This should be taken into account when choosing a contraceptive, especially for women with hormone-dependent fluid retention, as well as for women with acne and seborrhea. If used correctly, the Pearl Index (a measure reflecting the number of pregnancies in 100 women using a contraceptive during the year) is less than 1. If you skip pills or misuse, the Pearl Index may increase.

pharmachologic effect

Yarin is a low-dose monophasic oral combination estrogen-gestagenic contraceptive drug.

The contraceptive effect of Yarina is accomplished through complementary mechanisms, the most important of which are the suppression of ovulation and changes in the properties of the cervical secretion, as a result of which it becomes impermeable to spermatozoa.

If used correctly, the Pearl Index (a measure reflecting the number of pregnancies in 100 women using a contraceptive during the year) is less than 1. If you skip pills or misuse, the Pearl Index may increase.

In women taking combined oral contraceptives, the cycle becomes more regular, painful menstrual bleeding is less common, the intensity and duration of bleeding decreases, resulting in a reduced risk of iron deficiency anemia. There is also evidence of a reduction in the risk of endometrial and ovarian cancer.

Drospirenone, contained in Yarin, has an anti-mineralocorticoid effect and is able to prevent an increase in body weight and the appearance of other symptoms (for example, edema) associated with estrogen-dependent fluid retention.

Drospirenone also has antiandrogenic activity and helps reduce acne (acne), oily skin and hair. This effect of drospirenone is similar to the action of natural progesterone, produced by the female body. This should be taken into account when choosing a contraceptive, especially for women with hormone-dependent fluid retention, as well as for women with acne and seborrhea.

Instruction yariny

Yarin (ethinyl estradiol + drospirenone) is a low-dose, single-phase estrogen-gestagenic oral contraceptive. The contraceptive effect of the drug is realized through two complementary mechanisms: inhibition of ovulation and an increase in the viscosity of mucus in the cervical canal of the cervix. Oral contraception is by far the most common method of protection against unwanted pregnancy. It has no age restrictions within the reproductive period and is suitable for women who have already known the joy of motherhood, and for “first-born” (forgive the reader this obstetrical slang). Low-dose tablet contraceptives can be used up to the "red flags" of menopause. These drugs provide the following therapeutic effects: they reduce the volume, duration, and painful sensations during menstrual bleeding, alleviate the manifestations of premenstrual syndrome, and have a cosmetic effect on acne and seborrhea (the latter only for contraceptives with anti-androgenic effects, including yarin). In addition, oral contraceptives are considered a reliable means of preventing cancer of the ovaries and endometrium, apoplexy (rupture) of the ovaries, diseases of the mammary glands of non-oncological nature, hypermenorrhea, ectopic pregnancy and iron deficiency anemia. Speaking about the additional effects of oral contraceptives, it is necessary to note the drug Yarin, which is endowed with a unique property - to prevent fluid retention due to its effect on water-mineral metabolism. Extra kilograms ruthlessly exhibited by impartial weights are not the result of excess fat deposits, but fluid retention associated with the estrogen component of oral contraceptives. Drospirenone, the only progestin that does not cause estrogen-associated fluid retention in plasma and interstitial space, is part of Yarin.

The anti-mineralocorticoid effect of drospirenone prevents weight gain, prevents discomfort (swelling, tenderness, engorgement) in the area of ​​the mammary glands and high blood pressure. Reception of Yarina contributes to the excretion of only excess fluid accumulated in the body as a result of the action of estrogen. The effect of the drug on water-mineral metabolism can be compared with a low-salt diet that improves not only the subjective (well-being, mood), but also objective (appearance) parameters and characteristics. As the results of clinical studies show, Yarin is well tolerated. The weight of the participants in the trials of the drug remained stable, and some even tended to decrease. The overwhelming majority of patients expressed a desire to continue using Yarin after the end of the observation. The reason lies on the surface: according to surveys, the most frequent cause of a break in relations with oral contraceptives - in 36% of cases - is the increase in body weight. And since Yarin is devoid of such a side effect, her popularity in the women's “team” is not surprising. However, it is important to note that this drug, as well as other oral contraceptives, is contraindicated in women with obvious obesity, and certainly not a means for weight loss.

Before you start using Yarina, you should carefully analyze the family history and lifestyle of a woman, conduct an in-depth general medical and gynecological examination, incl. breast research and Papanicola test. The need, volume and frequency of additional and control studies are determined individually. As a rule, check-ups are carried out once a year (more often if necessary). Yarin does not protect against sexually transmitted infections.

Yarin: instructions for use, price, reviews, analogues

Contraceptive Yarin provides reliable protection against unwanted pregnancy and has a wide range of additional positive effects on the woman's body. The active components of the combined formulation of the drug create favorable conditions for the tolerance of the menstruation period and the alignment of the cycle. A distinctive feature of this oral contraceptive is a relatively small number of adverse events. However, despite being well tolerated, there is a certain list of contraindications to the use and features of therapeutic use. This necessitates a preliminary consultation with your doctor.

Pharmacokinetics

Drospirenone

When ingestion is rapidly absorbed. Highest content in of blood is reached after about an hour and a half. Bioavailability approaches 75-85%. Eating does not affect the level of bioavailability of drospirenone.

Associated in blood with albumin and is not associated with corticosteroid-binding globulin. In free form, only about 4% of the total serum is present.

Fully metabolized. Transformation products are represented by acid derivatives. drospirenonewhich are excreted with urine and feces in the ratio of 6/5. The half-life is approaching 40 hours.

In women with impaired liver function, the pharmacokinetic indices are comparable to those in healthy women, and the half-life of drospirenone in such patients is 1.8 times longer than in healthy individuals with normal liver function. In patients with impaired moderate liver function, a decrease in the clearance of drospirenone by half compared with healthy women was detected.

The concentration of drospirenone in the blood at the onset of equilibrium in women with mild renal impairment is comparable to that in healthy ones. And in women with moderately severe renal impairment, the level of drospirenone in the blood is 35% higher than in healthy women.

No fluctuations in the concentration of potassium in the blood when using drospirenone.

Ethinyl Estradiol

After use ethinyl estradiol actively absorbed. The highest content in the blood, as indicated by Wikipedia, is reached in an hour and a half. Metabolized in the liver, bioavailability is about 45%. The main method of transformation is aromatic hydroxylation. Approximately 98% of the substance molecules are bound by albumin.

In unchanged form from the body is not excreted. Ethinyl estradiol derivatives are evacuated with urine and bile. The half-life is 24 hours.

Contraindications

Contraindications to the use of tablets Yarin:

  • current and past thrombosis and thromboembolism (including stroke, venous thrombosis, myocardial infarction, pulmonary thromboembolismcerebrovascular changes
  • current and past pancreatitis with hypertriglyceridemia,
  • current and past prethrombotic states (including angina pectoris, ischemic attacks),
  • current and past migraine with neurological symptoms,
  • diabetes with vascular complications,
  • risk factors vascular thrombosis, eg, atrial fibrillation, complicated valve changes of the heart, vascular diseases of the brain or heart, surgical intervention followed by prolonged immobilization, arterial hypertensionsmoking after 35 years
  • decompensated renal failure or acute kidney failure,
  • liver failure or severe liver disease (until normalization of tests),
  • current and past liver tumors,
  • hormone-dependent malignant tumors or suspicion of them,
  • bleeding from the vagina of unexplained origin,
  • lactation,
  • pregnancy or suspicion of pregnancy
  • hypersensitivity to the drug.

If any of the above disorders develop for the first time while taking the medicine, it should be canceled immediately.

Yarin hormonal tablets should be taken with extreme caution if you have any of the following conditions or diseases:

  • risk factors for thrombosis: obesity, smoking, arterial hypertension, dyslipoproteinemiaextensive injury migraine, prolonged immobilization, valvular heart disease, surgical interventions, hereditary predisposition to development thrombosis,
  • other diseases that can provoke changes in peripheral circulation or superficial phlebitis,
  • hypertriglyceridemia,
  • angioedema hereditary genesis,
  • liver disease,
  • postpartum period
  • diseases that have arisen or become complicated during pregnancy or the last hormonal intake (porphyria, jaundice, herpes pregnant cholelithiasis, otosclerosis, chorea).

Side effects

As with other combined contraceptives, Yarin’s side effects such as thromboembolism or thrombosis.

Side effects of Yarina:

  • from the side sexual sphere: vaginal or breast discharge, pain and enlargement of the mammary glands,
  • from the side digestion: vomiting, abdominal pain, nausea, diarrhea,
  • from the side of view: discomfort when using contact lenses,
  • frustration nervous activity: mood deterioration, mood changes, weakening or strengthening libido, headache, migraine,
  • leather: erythema nodosumrash urticaria, erythema multiforme,
  • on the part of metabolism: weight change, water retention in the body,
  • other disorders: allergic reactions.

Yarin tablets, instructions for use

The drug is taken 1 tablet per day for 3 weeks. Taking pills from the next pack should be started after a seven-day break with the usually developing "bleeding withdrawal". It starts about 3 days after consuming the last pill and is able to continue up to the use of pills from a new blister.

Start receiving

How to take the first time Yarin?

In the absence of the use of any hormonal contraceptives in the previous month, the use of the drug begins on the 1st day of the menstrual cycle. It is also possible to start using on the 2-5 day of the menstrual cycle, but in this case you need to use a barrier method of contraception in the 1st week of admission.

If the patient moves from other oral combination contraceptives, contraceptive patch or vaginal ringit is desirable to start using the medication on the day following the last tablet of the “old” drug, but no later than the next day after the standard 7-day break (for products containing 21 tablets) or after consuming the final inactive tablet (for products containing 28 tablets ). When using a vaginal ring or a contraceptive patch, use of the medication should be started on the day the patch or ring is removed, but no later than the day the new ring or patch is established.

Transition with contraceptive (mini drankcontaining only progestin) at Yarina can be done on any day (without a temporary break). Transition with implantcontaining only progestin, or progestin-releasing intrauterine contraceptive - on the day of its extraction. Transition with injection form- from the day on which the following procedure should be performed. In all of the above cases, you need to use a barrier method of contraception in the 1st week of admission.

After delivery or performance abortion in the second trimester, medication should be started no earlier than 4 weeks after the last birth (provided that the mother does not breastfeed) or an abortion. If the application is started later, you need to use a barrier method of contraception in the 1st week of admission.But if the patient has already had sexual intercourse, it is necessary to exclude pregnancy or wait for the 1st menstruation before the start of Yarina’s use.

After an abortion in the 1st trimester of pregnancy, it is allowed to start taking the medicine - on the day of the abortion. When this condition is fulfilled, the patient does not need additional methods of contraception.

Missed pills

If the medicine was taken with less than 12 hours lateContraceptive protection does not go down. A woman needs to take a pill as quickly as possible, the next pill is taken at the usual time.

If the medicine was taken with over 12 hours late, contraceptive protection is reduced. The greater the number of pills missed, the greater the likelihood of pregnancy. If you skip 1 tablet, the probability of becoming pregnant is minimal. If you are late for more than 12 hours, follow the recommendations below.

Pass is made in the first 7 days of taking the drug

You need to use the last missed pill as soon as possible, even if you want to take 2 pills together. The next pill is taken at the usual time. It is recommended to use a barrier method of contraception for one more week. If sexual intercourse took place within 7 days before the tablet is missed, the likelihood of pregnancy should be considered.

Pass was made at 8-14 day of taking the drug

You need to use the last missed pill as soon as possible even if you want to take 2 pills together. The next pill is taken at the usual time. If the patient has taken the pills correctly over the past 7 days, then there is no need for additional contraceptive measures. Otherwise, or if you skip 2 or more pills, you must additionally use barrier methods of contraception for another week.

Pass is made on the 15-21 day of taking the drug

The risk of pregnancy increases due to the impending temporary interruption in the intake of the drug. The patient should perform one of the following two options. In this case, if during the last week the pill regimen was observed, then there is no need to apply additional methods of contraception.

  • It is necessary to take the last missed pill as soon as possible, even if it means that you need to take 2 pills at the same time. Subsequent tablets from the current package are consumed as usual until they run out. The following packaging should be started without interruption. Until the tablets from the second package run out, withdrawal bleeding is unlikely, but breakthrough bleeding and spotting during the use of tablets is not excluded.
  • It is necessary to stop the use of pills from the current blister and start a seven-day break, and then start taking the medicine from the new blister. If the patient has violated the pill regimen and during the seven-day break she did not develop withdrawal bleeding, it is necessary to exclude pregnancy.

With vomiting and diarrhea

In the event of vomiting or diarrhea within four hours after taking the pills, perhaps not completely absorbed. In this case, additional contraceptive measures should be taken, as well as the need to focus on the above recommendations when skipping pills.

Interaction

The use of drugs that stimulate the liver microsomal enzymesmay cause an increase in excretion of genital hormones, which causes breakthrough bleeding or weakening of the reliability of contraception. These drugs include Phenytoin, Primidone, barbiturates, Rifampicin, Carbamazepine, Rifabutin other.

Penicillins and Tetracycline capable of lowering the enterohepatic circulation estrogen, thereby reducing the concentration ethinyl estradiol. During the period of use of drugs that affect microsomal enzymes, and about a month after the completion of their admission should use barrier contraception.

Combined contraceptives can alter the metabolism of other drugs, which leads to an increase or decrease in their concentration in the blood and tissues.

special instructions

Prior to the commencement or resumption of use of the drug, it is necessary to familiarize oneself with the personal and family history, conduct a gynecological and general medical examination, and exclude the presence of pregnancy. The structure and scope of research, as well as the regularity of inspections is determined in each individual case individually. Standard control examinations should be carried out at least once a year.

The patient should be informed that the drug does not protect against infection. HIV infection and other sexually transmitted diseases.

The relationship between taking combined contraceptives and increasing the frequency of vascular thrombosis and thromboembolismincluding pulmonary artery thrombosis, venous thrombosis,myocardial infarction, vascular disorders of the brain.

Risk of occurrence venous thromboembolism highest in the 1st year of taking these drugs. Increased risk occurs after the initial use of oral contraceptives or the resumption of their use.

Arterial thromboembolism, the risk of which also increases when taking drugs like Yarina, can lead to vascular occlusion, stroke or heart attack. Signs of a stroke: weakness or loss of sensitivity of the face or limbs, problems with speech and her understanding, confusion, sudden loss of vision, dizziness, gait disturbance, causeless headache, loss of balance, loss of consciousness. Other signs of vascular occlusion: swelling, sudden pain, blue limbs, severe pain in the abdomen.

Signs of heart attack: heaviness, discomfort, pain, pressure, feeling of tightness in the arm or chest, discomfort, giving to the cheekbone, back, arm, larynx, stomach, nausea, cold sweat, vomiting or dizziness, anxiety, weakness, dyspnea, tachycardia.

Arterial thromboembolism can lead to death.

Risk of occurrencethrombosis and thromboembolism increases:

  • for smokers
  • with age,
  • with obesity
  • in the presence of thromboembolismever with next of kin or parents
  • during prolonged immobilization, surgery, operations on the lower limbs (in these situations, it is desirable to stop the use of combined contraceptives and not to resume it for 15 days after completion of immobilization),
  • at hypertension,
  • at dyslipoproteinemia,
  • with valvular heart disease,
  • at migraine,
  • at atrial fibrillation.

Increased frequency and severity of attacks migraine during the use of combined contraceptives may be grounds for termination of their admission.

Rarely against the background of the use of combined contraceptives, benign liver tumors were observed, and extremely rarely malignant.

In patients withhypertriglyceridemia increase of probability of development is not excludedpancreatitiswhen taking drugs like Yarina.

In women with hereditary Quincke's edemaexogenous estrogens able to cause or worsen the course of this disease.

Irregular bleeding or bleeding may occur during combined contraceptive use, especially during the first months of use. Therefore, an assessment of irregular bleeding of any nature should be carried out only after the completion of the adaptation period of approximately 3 cycles.

If the above bleeding is repeated, it is necessary to conduct an examination and examination to exclude malignant tumors or pregnancy.

As the consequences of withdrawal in some patients with a break in reception or discontinuation of pills may develop bleeding.

Acceptance of Yarina can alter the results of a number of laboratory tests, for example, the performance of the liver, kidneys, adrenal glands, thyroid gland, the content of carrier proteins, the state coagulationcarbohydrate metabolism and fibrinolysis.

The drug does not affect the ability to drive.

Which is better: Midiana or Yarin?

Midianaand Yarin are complete analogs in composition and proportion of the components in the preparation. Reviews testify to the absence of fundamental differences in the effect of these two agents. Midian is cheaper in cost. The choice is made on the basis of economic considerations and individual portability.

Which is better: Novinet or Yarin?

Novinet and Yarin differ somewhat in active ingredients, but not in the mechanism of action. By cost Novinet is almost 2 times cheaper, and in addition to contraceptive action, it reduces the risk of development iron deficiency anemia. The choice is made based on the recommendations of the doctor and economic considerations.

Yarin and Yarin Plus

Differences Yarina and Yariny Plus consist in the fact that the last drug contains additional calcium levomefolatreducing deficit folatein the body of a woman and the fetus in case of an unplanned pregnancy. Drug prices are comparable.

During pregnancy and lactation

The drug is not prescribed for pregnancy and lactation.

If pregnancy was detected during the application of Yarina, the medication should be immediately canceled. Studies have not revealed an increased risk of developmental defects in newborns whose mothers took sex hormones before the development of pregnancy or in its early stages. At the same time, the use of combined contraceptives can reduce the volume of breast milk and change its composition, so the use of such drugs is not recommended until breastfeeding is completed.

Reviews of Yarin

Reviews of doctors about Yarin quite restrained characterize the drug, which has its own advantages and disadvantages.

An online forum reports that a fairly large number of women taking Yarin hormone pills developed a variety of side effects: from acne and other skin changes to severe vascular disorders. Other reviews reported that birth control pills on the contrary have a beneficial effect on the skin and are recommended for polycystic ovary.

Doctors reviews about tablets when endometriosis indicate positive results of treatment with continuous administration. Such a scheme of application contributes to the oppression of menstrual function, inhibits retrograde blood flow to the pelvic organs and stimulates regression in endometrioid heterotopias. Reception duration at endometriosis is not less than six months.

Reviews about Yarin after cancellation are usually satisfactory, but sometimes there may be changes in the form of weight gain or appearance. acne. There are a number of messages from the fact that after the cancellation there is no monthly. The situation is considered normal if there are no menstrual periods within 4-5 days after the end of taking contraceptives. But in the case when they do not appear within a week, you should consult a gynecologist for advice.

Side effects

  • The most frequent side effect when taking oral contraceptives is the occurrence of irregular bleeding from the vagina. They can manifest as spotting or breakthrough bleeding. Most often they occur during the first three months.
  • Other side effects associated with taking Yarina can be soreness, engorgement or discharge from the mammary glands, as well as vaginal discharge.
  • On the part of the nervous system, there may be such changes as headache, changes or decrease in mood, decrease or increase in libido, migraine.
    Digestive disorders can manifest as nausea, abdominal pain, less vomiting or diarrhea.
  • Sometimes when taking Yarina there is intolerance to contact lenses, there are unpleasant sensations while wearing them.
  • Metabolic disorders are manifested by a change in body weight - more often by an increase, less often - by its decrease, a delay in the body's fluid.
  • Skin manifestations of hypersensitivity to the drug are represented by urticaria, rash, less often the appearance of erythema nodosum.
  • Like the others contraceptives with hormonal composition, in rare cases when taking Yarina may develop thrombosis or thromboembolism.

The first packaging Yariny

1. In the case when no contraceptive containing hormones was applied in the previous month, it is best to start taking Yarina on the first day of menstruation. From the package, choose a pill labeled with the appropriate day of the week. Then they should be drunk in the order indicated by the arrow. It is also allowed to start taking on the 2-5 day of the cycle, in this case, during the first 7 days of taking the pills, you should use additional methods of contraception (for example, a condom).

2. If it is necessary to switch to taking Yarin from other combined oral contraceptives, the first pill is taken without interruption. Thus, if the previous remedy contained 28 pills, taking Yarina begins after the last active pill is drunk, but no later than the day of the last inactive pill. If the product contained 21 pills, take Yarina no later than the next day after a 7-day break.

3. In the case of using a vaginal ring or a hormonal patch, the reception of Yarina begins on the day when they were removed, but not later than the day the next ring was inserted or the patch was glued.

4. If before the reception of Yarina, products containing only the gestagen (mini-pilli) were used, their reception can be interrupted on any day, and you can start drinking Yarin. It is necessary to use the barrier method of protection during the first week.

5. When switching to Yarina from an injection, implant, or Mirena intrauterine device, taking the pills is started on the day when the next injection was supposed to be taken, to remove the implant or intrauterine contraceptive. After that, for 7 days, in addition to Yarina, use barrier methods of contraception.

6. After delivery, doctors recommend waiting until the end of the first normal cycle of menstruation, then start taking Yarina. In some cases, you can start taking it earlier, but only on the advice of a doctor.

7. After an abortion made in the first trimester of pregnancy, or after a miscarriage, doctors are often advised to immediately begin taking the drug.

Missing a pill in the third week - options

Additional methods of protection can not be used if the previous (second) week of taking all the tablets were taken as expected. There are 2 options for the subsequent intake of tablets:

1. You can take a pill as soon as a pass is found, then drink the next one (even if you have to take two at once). Finish the current packaging, and then without a 7-day break, start taking the next one. In this case, withdrawal bleeding will not begin, but spotting and breakthrough bleeding are likely.

2. Stop taking the pills and take a break of 7 days or less (including the day when the tablet was missed), then start taking the next pack. Under this scheme, you can begin to take the next pack on the day of the week, which usually begins receiving.
If during the break in the reception does not come withdrawal bleeding, it is necessary to consult with your doctor to exclude pregnancy.

Reception Yarina in special cases

For children and adolescents, the drug can be taken only after the onset of menarche (first menstruation).

In the elderly, the drug is not used, it is not indicated after the establishment of menopause.

In case of violations of the liver, the drug can not be taken until the indicators characterizing the function of the liver (liver function tests) return to normal.

Caution must be exercised in violation of the functioning of the kidneys, since the drug is contraindicated in acute or severe renal failure.

Monthly while taking Yarina

Menstruation occurs during the week break, most often on the 2-3rd day, approximately on the same day of the week (provided that it is properly taken). If desired, it is possible to change the day the menstruation occurs. To postpone the beginning of menstruation, you should not take a 7-day break, but start taking the next pack of pills after the end of the current one. You can take the pills until the end of the package or, if you wish, stop taking it on any day (then the menstruation will begin). While taking the pills from the second pack, lung discharge or bleeding is likely. The following package Yarin take after a break of 7 days, as usual.


To change the day of the beginning of the month, you need to shorten the 7-day break in reception. Thus, menstruation will begin earlier. If the break was less than 3 days, the menstruation may not start, but instead, bleeding or spotting may occur while taking the next pack of Yarina.

When do I need to see a doctor?

When taking Yarina, the doctor should be visited regularly - at least once a year for preventive examinations.

The doctor should be visited as early as possible if the following situations arise:
1. When any changes in health, especially conditions in which the tool is used with caution, or in which it is contraindicated.
2. If a limited compaction has appeared in the mammary gland.
3. When the need arises to take other medicines.
4. If there is a long-term immobility, bed rest - for example, as in the case of the application of gypsum or surgery.
5. When vaginal bleeding occurs, which is stronger or more abundant than usual.
6. In the case of missing the pill in the first week of admission, if there was sexual intercourse in the previous 7 days.
7. If menstruation does not occur 2 times in a row, or there is a suspicion of pregnancy.

Reviews of patients about Yarin

Asya, 21 years old.
Hello. Yarinu accept 3 years. Again, I can not say anything, my skin has become better, PMS is not so worried. Menstruation became not so painful and plentiful, besides the cycle became stable. And before that, and for 3 months could not be. I was prescribed pills for indications, because of a cyst, but now it is not there, everything is fine. Before that, the other pills drank — they didn’t fit, they just suffered. You should always remember that everything is individual, and it is never too late to cancel the reception of funds.

Catherine, 24 years old.
I took Yarina for 5 years, I have a tendency to lose weight and lose my appetite. At Yarin my weight was normal, I began to eat, my skin became better, I didn’t feel menstruation at all. But there is one thing - I went to the gynecologist, they told me that the walls of my uterus were exhausted. She stopped taking and did not drink the tablets for a year and a half. Now I accept again, and I like the drug.

Diana, 26 years old.
Yarinu saw the year. She planned to have a baby and got pregnant on the second cycle without pills. Bore without any problems. Now, again, I began to drink Yarina after a three-year break. I can not say that everything is as good as before pregnancy. There were spotting bleeding, stomach pulls. I hope that this is addictive to the drug.

Yarin - reviews of doctors

In most cases, reviews of doctors about Yarin are positive. Since the drug contains low doses of hormones, it has, in addition to the contraceptive, also anti-mineralocorticoid action (the ability to reduce edema and fluid retention in the body) and anti-androgenic effect (suppressing the action of male sex hormones with their excess) - it can be prescribed for therapeutic and prophylactic purposes. According to the doctors, the majority of side effects occur in untreated or insufficiently examined women.

Today it is believed that Yarin is able to reduce the risk of the following diseases:

  • ovarian and uterine cancer,
  • inflammation of the genital organs,
  • ectopic pregnancy,
  • breast mastopathy and tumors,
  • osteoporosis (decreased bone density) during menopause.

Dosage Form

The dosage form of the Yarin contraceptive release is light yellow round, biconvex film-coated tablets. On one side is a hexagon with “DO” letters engraved inside it.

The drug is packaged in cardboard packaging containing 1 or 3 blisters of 21 tablets.

Indications for use of tablets Yarin

  • Preventing unwanted pregnancy (contraception),
  • Acne and seborrhea in women, as well as hormone-dependent fluid retention.

Yarin can be used as a treatment for endometriosis, adenomyosis, uterine myoma, polycystic ovary and some other gynecological diseases.

Description and composition

Yarin is a combined agent, the active elements of which are the following substances:

  • Drospirenone - 3 mg / tab.,
  • ethinyl estradiol - 30 µg / tab.

  • lactose monohydrate,
  • titanium dioxide,
  • macrogol 6000,
  • iron oxide II,
  • talc,
  • povidone,
  • corn starch (gelled),
  • magnesium stearate,
  • hypromellose.

Pharmacological group

Yarin is a monophasic low-dose contraceptive medication with a combination of the composition. The drug has antiandrogenic and anti-mineralocorticoid properties. The main therapeutic effect of the agent is to suppress the secretory ability of the pituitary hormones, prevent ovulation and slow down the maturation of the follicles. Yarin helps to increase the viscosity of the liquid of the cervical canal, which leads to preventing sperm from entering the uterine cavity. Drospirenone has a pronounced anti-mineralocorticoid effect, which prevents the increase in body weight and other effects of water retention in the body. The substance interferes with estrogen retention of sodium and creates conditions for positive tolerability with premenstrual syndrome.

Drospirenone has a powerful anti-androgenic effect, which has a positive effect on reducing the activity of the sebaceous glands and the formation of acne. In combination with ethinyl estradiol, the substance significantly improves the lipid profile and contributes to an increase in high-density lipoprotein levels.

Drospirenone does not have glucocorticoid, androgenic, antiglucocorticoid or estrogenic activity, which, in combination with antiandrogenic and antimineralocorticoid property, brings the substance closer to the natural hormone progesterone.

Yarin does not prevent the increase in the concentration of globulin that binds sex hormones. This effect contributes to the suppression of endogenous androgen activity.

While using this drug, there is a high probability of preventing the development of ovarian and endometrial cancer.

Yarin contributes to the alignment of the menstrual cycle, as well as reducing the manifestation of painful menstruation and profusion of discharge, which prevents the manifestation of iron deficiency anemia.

Drospirenone is almost completely absorbed from the gastrointestinal tract. The maximum concentration of a substance in the serum is observed 1–2 hours after the first dose.

Bioavailability ranges from 75 to 85%. Meal does not affect this indicator.

Drospirenone tends to be completely metabolized in the liver. Metabolism products are excreted in the urine and feces. The average half-life averages 40 hours.

for adults

Indications for the use of drugs are:

  • prevention of unwanted pregnancy,
  • hormone-dependent fluid retention
  • seborrhea,
  • downed menstrual cycle
  • acne
  • menstrual pain, accompanied by copious discharge.

Application of the tool in childhood and adolescence is possible only after the onset of menarche (first menstrual bleeding).

for pregnant women and during lactation

Pregnant and lactating women are strictly contraindicated to take the drug Yarin.

Contraindications

  • thrombosis,
  • diabetes mellitus, accompanied by vascular complications,
  • pregnancy and lactation,
  • chronic liver failure
  • hypersensitivity to the components of the drug,
  • non-menstrual vaginal bleeding,
  • the presence of benign or malignant tumors,
  • children's age before menarche,
  • angina pectoris,
  • coronary heart disease,
  • acute form of renal failure,
  • various failures in the liver.

Uses and doses

The product should be taken at the same time in the order indicated on the packaging. Interrupting the course and skipping techniques is highly undesirable because of the weakening of the contraceptive effect of the drug.

for adults

Yarin is recommended to take 1 tablet per day for three weeks. A second course is possible only seven days after the end of the previous one. Between courses, so-called “withdrawal bleeding” may occur. Most often this effect is observed in the last days before the cessation of the course and can last up to the second or third day of the new admission period.

It is recommended to start the application of Yarina directly on the first day of the beginning of the cycle (the first day of the menstrual bleeding). It is possible to shift the start of the reception for 2-3 days, but in this case, the first week of use should be accompanied by the use of barrier contraceptives.

The effect of the drug decreases 12 hours after the last dose. If the admission admission has not gone beyond 12 hours, you should take the dose as soon as possible. In this case, the usual time of constant use is not shifted.

Do not interrupt the medication for more than 7 days. In the case of a long break in use, it is necessary to use barrier-type contraceptives.

The use of Yarin for children is possible only after the onset of the first menstrual bleeding. Dosage is selected individually.

for pregnant women and during lactation

During pregnancy and during breastfeeding, the intake of the drug Yarin is strictly prohibited. In case of emergency use during lactation should stop breastfeeding immediately.

Overdose

The main and most common signs of an overdose with Yarin's remedy are the following states:

  • Vaginal bleeding of various etiologies and structures
  • gagging,
  • metrorrhage
  • nausea.

The following drugs can be used instead of Yarina:

  1. Janine is a partial analogue of the drug Yarin. It is produced in pills, which are prescribed to prevent unwanted pregnancy.
  2. Regulon is a monophasic combined contraceptive. The drug is produced in tablets, the contraceptive effect of which is due to incoming desogestrel and ethinyl estradiol.
  3. Jes belongs to the monophasic combined contraceptives, providing antiandrogenic effect. The drug is produced in tablets, which are prescribed for protection from unwanted pregnancy, treatment of acne, premenstrual syndrome.
  4. Lindinet 20 is a substitute for Yarina in the clinical pharmacological group. The therapeutic effect of oral monophasic contraceptive is explained by gestodene and ethinyl estradiol. The drug is produced in tablets.

Pregnancy and lactation

Yarina can not be used during pregnancy and during lactation. If pregnancy is detected while taking Yarin, the drug should be immediately canceled and consult a doctor. However, extensive epidemiological studies have not revealed an increased risk of developmental defects in children born to women who received sex hormones before pregnancy, or when taking sex hormones through negligence in the early stages of pregnancy.

Taking combined oral contraceptives can reduce the amount of breast milk and change its composition, so their use is not recommended until breastfeeding is stopped.

Dosage and administration

Calendar pack contains 21 pills. In the packaging, each tablet is labeled the day of the week in which it must be taken. Take the pill inside at the same time every day with a small amount of water. Follow the direction of the arrow until all 21 tablets are taken. For the next 7 days, you are not taking the drug. Menstruation (withdrawal bleeding) should begin within these 7 days. It usually starts 2-3 days after taking the last pill.

Yarin. After a 7-day break, start taking the following pills from the package, even if the bleeding has not stopped. This means that you will always start taking pills from a new pack on the same day of the week, and that each month you will be able to stop bleeding around the same day of the week.

Taking pills from the first package of Yarina

• When no hormonal contraceptive was used in the previous month.

Start taking Yarina on the first day of the cycle, that is, on the first day of menstrual bleeding. Take a pill that is labeled with the appropriate day of the week. Then take the pills in order. You can also start taking it on the 2nd-5th day of the menstrual cycle, but in this case, you must use an additional barrier method of contraception (condom) during the first 7 days of taking the pills from the first package.

• When switching from other combined oral contraceptives, a vaginal ring or a contraceptive patch.

You can start taking Yarina the next day after you take the last pill of the current package of the combined oral contraceptive (i.e., without interruption in the intake). If the current package contains 28 tablets, you can start taking Yarina the next day after taking the last active tablet. If you are not sure which tablet to use, ask your doctor. You can also start taking it later, but in no case no later than the next day after the usual break in reception (for drugs containing 21 tablets) or after taking the last inactive tablet (for drugs containing 28 tablets per pack).

Reception of Yarina should be started on the day of removal of the vaginal ring or patch, but no later than the day when a new patch is to be inserted or a new patch is pasted.

• When switching from oral contraceptives containing only gestagen (mini-drank)

You can stop taking a mini-drink on any given day and start taking Yarina the next day, at the same time. During the first 7 days of taking the pills, you must also use an additional barrier method of contraception.

• When switching from an injection contraceptive, an implant, or a progestogen-releasing intrauterine contraceptive (Mirena)

Start taking Yarina on the day when the next injection is to be given or on the day of the removal of the implant or intrauterine device. During the first 7 days of taking the pills, you must also use an additional barrier method of contraception.

If you have just given birth to a child, your doctor may recommend that you wait until the end of the first normal menstrual cycle before you start taking Yarina. Sometimes, on the recommendation of a doctor, it is possible to start taking the drug earlier.

• After spontaneous or medical abortion in the first trimester

Check with your doctor. It is usually recommended to start taking it immediately.

Taking missed pills

• If the delay in taking the next pill is less than 12 hours,

The contraceptive effect of Yarina is preserved. Take the pill as soon as

remember this. Take the next pill at the usual time.

• If the delay in taking the pills is more than 12 hours, contraceptive protection may be reduced. The more pills in a row are missed, and the closer this pass is to the beginning of reception or to the end of reception, the higher the risk of pregnancy.

In this case, you can follow the following rules:

• More than one tablet out of the box. Consult your doctor.

• One tablet missed in the first week of taking the drug

Take the missed pill as soon as possible as soon as you remember (even if it means taking two pills at the same time). Take the next pill at the usual time. Additionally, use a barrier method of contraception for the next 7 days. If sexual intercourse took place during the week before skipping the pill, it is necessary to consider the probability of pregnancy. Consult a doctor immediately.

• One tablet missed on the second week of taking the drug.

Take the missed pill as soon as possible as soon as you remember (even if it means taking two pills at the same time). Take the next pill at the usual time. If you took the pills correctly for 7 days preceding the first missed pill, the contraceptive effect of Yarina remains, and you do not need to use additional contraceptive measures. 7 days.

• One pill missed on the third week of taking the drug

If during the 7 days preceding the first missed pill, all pills were taken correctly, there is no need to use additional contraceptive methods. You can follow either of the following two options, without the need for additional contraceptive measures.

1. Take the missed pill as soon as possible as soon as you remember (even if it means taking two pills at the same time). Take the next pill at the usual time. Start taking the pills from the next package immediately after taking the tablets from the current package, so there will be no break between the packages. "Cancellation" bleeding is unlikely until the tablets from the second package run out, but there may be spotting or "breakthrough" bleeding on the days of taking the drug.

2. Stop taking the pills from the current pack, take a break of 7 days or less (including the day you skip the pills), and then start taking the pills from the new pack.

Using this scheme, you can always start taking pills from the next pack on the day of the week when you usually do it.

If, after a break in taking the pills, there is no expected menstruation, you may be pregnant. Check with your doctor before you start taking new packaging.

Recommendations in case of vomiting and diarrhea

If you had vomiting or diarrhea (indigestion) within up to 4 hours after taking Yarina's tablets, the active substances may not have fully absorbed. This situation is similar to skipping the drug. Therefore, follow the instructions for the missed pills.

Delay in the onset of menstruation

You can delay the onset of menstruation if you start taking pills from the next pack of Yarina immediately after the end of the current pack.You can continue taking the pills from this package for as long as you like, or until the pills from this package run out. If you want your period to start, stop taking the pills. During the reception of Yarin from the second package may be spotting or bleeding on the days of taking the pills. Take the pills from the next package, start after the usual 7-day break.

Change the day of the onset of menstruation

If you take pills as recommended, you will have menstruation about the same day every 4 weeks. If you want to change it, shorten (but do not lengthen) the time free from taking pills. For example, ifyapt The menstrual cycle usually begins on Friday, and in the future you want it to start on Tuesday (3 days earlier), you need to start taking the tablets from the next package 3 days earlier than usual. If the break free from taking the pill is very short (for example, 3 days or less), menstruation during the break may not occur. In this case, bleeding or spotting may occur while taking the tablets from the next package. Additional information for special patient categories Children and teenagers

The drug Yarin is shown only after the onset of menarche. The available data do not suggest dose adjustment in this group of patients.

Elderly patients

Not applicable. The drug Yarin is not indicated after menopause.

Patients with hepatic impairment

The drug Yarin is contraindicated in women with severe liver disease, as long as liver function indicators do not return to normal. See also the section "Contraindications".

Kidney impaired patients

The drug Yarin is contraindicated in women with severe renal insufficiency or acute renal failure. See also the section "Contraindications".

Side effect

While taking the drug Yarin, like any other drugs, adverse reactions may occur, although their appearance is not necessary in all patients. If any adverse reaction becomes serious or you notice an adverse reaction in yourself that is not mentioned in this manual, please inform your doctor or pharmacist.

Serious adverse effects:

In the event of adverse effects, including serious reactions associated with the use of the drug, see the sections "With caution", "Special instructions" and "Contraindications". Please read these sections carefully and consult with your doctor if necessary. The following adverse reactions have been reported in women using Yarin:

Frequent unwanted effects (more than 1/100 and less than 1/10):

□ mood swings, depression / depressed mood

□ decrease or loss of libido (decrease or loss of sexual desire)

□ pain in the mammary glands, irregular uterine bleeding (“breakthrough” bleeding), bleeding from the genital tract (bleeding from the vagina) of unspecified origin

Rare unwanted effects (more than 1/10000 and less than 1/1000):

□ venous or arterial thromboembolism *

□ * Approximate frequency of epidemiological studies covering a group of combined oral contraceptives. Frequency bordered on very rare.

□ “Venous or arterial thromboembolism” includes the following nosological units: peripheral deep vein occlusion, thrombosis and

pulmonary embolism / occlusion, thrombosis, embolism and infarction / myocardial infarction / cerebral infarction and stroke, not defined as hemorrhagic.

Side effects that were reported during the application of Yarina, but the assessment of the frequency of occurrence of which was not possible: erythremus multiforme (skin condition characterized by itchy red rashes or localized swelling of the skin).

The following are the side reactions with a very rare occurrence or delayed symptoms, which are believed to be associated with taking drugs from the group of oral combined contraceptives (see also "Contraindications" and "Special Instructions").

□ The frequency of diagnosing breast cancer in women taking combined oral contraceptives is somewhat increased. Due to the fact that breast cancer is rarely observed in women under 40 years old, an increase in the number of breast cancer diagnoses in women taking combined oral contraceptives is insignificant relative to the overall risk of this disease.

□ Women with hypertriglyceridemia (increased risk of pancreatitis while taking combined oral contraceptives).

□ Increased blood pressure.

□ Conditions developing or worsening while taking combined oral contraceptives, but their relationship has not been proven: jaundice and / or pruritus associated with cholestasis, formation of gallstones, porphyria, systemic lupus erythematosus, hemolytic-uremic syndrome, Sydangam chorea, herpes pregnant women, hearing loss associated with otosclerosis.

□ In women with hereditary angioedema, estrogen administration may cause or worsen its symptoms.

□ Liver dysfunction.

□ Impaired glucose tolerance or effect on insulin resistance.

□ Crohn's disease, ulcerative colitis.

□ Hypersensitivity (including symptoms such as rash, urticaria). Interaction

The interaction of oral contraceptives with other medicinal

agents (inducers of liver microsomal enzymes, some antibiotics)

can lead to

breakthrough bleeding and / or reduction of contraceptive efficacy (see. "Interaction with other drugs").

Application features

The following warnings related to the use of other combination oral contraceptives should be taken into account when using Yarin.

Thrombosis is the formation of a blood clot (thrombus) that can clog a blood vessel. With the separation of a blood clot thromboembolism develops. Sometimes thrombosis develops in the deep veins of the legs (deep vein thrombosis), heart vessels (myocardial infarction), brain (stroke), and very rarely in the vessels of other organs.

The results of epidemiological studies indicate a relationship between the use of combined oral

contraceptives and increased incidence of venous and arterial thrombosis and thromboembolism (such as deep vein thrombosis, pulmonary embolism, myocardial infarction, cerebrovascular disorders) when taking combined oral contraceptives. These diseases are rare.

The risk of venous thromboembolism (VTE) is maximum in the first year of taking such drugs. Increased risk is present after the initial use of combined oral contraceptives or the resumption of the use of the same or different combined oral contraceptives (after a break between taking the drug in 4 weeks or more). Data from a large study show that increased risk is present predominantly during the first 3 months.

General risk of VTE in patients taking low-dose combination oral contraceptives (0

Instructions for use of tablets Yarin, dosage

Tablets should be taken orally in the order indicated on the package, every day at the same time, without chewing, with a small amount of water.

Calendar pack contains 21 pills. In the packaging, each tablet is labeled the day of the week in which it must be taken. Take the pill inside at the same time every day with a small amount of water. Follow the direction of the arrow until all 21 tablets are taken. For the next 7 days, you are not taking the drug. Menstruation (withdrawal bleeding) should begin within these 7 days.

If you took other birth control pills and now you want to go to Yarina, follow these rules:

If there were 28 pills in the blister pack of the previous birth control pills, then the first pill of Yarin should be started the next day after the end of the 28 pills of the previous ones.

If the packaging of the previous OK was 21 pills, then the first Yarin pill can be started the next day after the end of the blister of the previous birth control pills, or on the 8th day after the seven-day break.

Application features

Reviews of Yarin indicate that the contraceptive effect of birth control pills is not reduced in cases of interruption in the reception of not more than 12 hours. The likelihood of pregnancy increases with increasing break between taking pills. The missed pill contraceptive should be drunk as soon as possible. A gradual increase in the number of missed pills also leads to pregnancy.

If the delay in taking the drug was less than 12 hours, contraceptive protection is not reduced. A woman should take a pill as soon as possible, the next pill is taken at the usual time.

If the delay in taking the drug was more than 12 hours, contraceptive protection is reduced. The more pills are missed, and the closer the pass to the 7-day break in taking pills, the greater the likelihood of pregnancy.

The drug does not affect the ability to work with precise mechanisms and drive vehicles.

The contraceptive effect of Yarina can be reduced by vomiting, diarrhea, taking large doses of alcohol, taking certain medications.

Use during pregnancy and lactation

The drug is not prescribed during pregnancy and during lactation. If pregnancy is detected while taking Yarin ®, it should be canceled immediately. However, extensive epidemiological studies have not revealed an increased risk of developmental defects in children born to women who received sex hormones prior to pregnancy or a teratogenic effect in cases of taking sex hormones through negligence in the early stages of pregnancy. At the same time, data on the results of taking Yarin ® during pregnancy is limited, which does not allow any conclusions about the negative impact of the drug on pregnancy, the health of the newborn and the fetus. There are currently no significant epidemiological data available.

Taking combined oral contraceptives can reduce the amount of breast milk and change its composition, so their use is not recommended until breastfeeding is stopped. A small amount of sex steroids and / or their metabolites can be excreted in milk.

Analogs of tablets Yarin list

Similar drugs in action:

  1. Jess (Yaz),
  2. Dimia,
  3. Daylla,
  4. Midiana (Midiana),
  5. Diane-35 (Diane-35),
  6. Regulon,
  7. Marvelon (Marvelon),
  8. Jeanine (Jeanine),
  9. Lindinet 30 (Lindynette 30),
  10. Levonorgestrel (Levonorgestrel),
  11. Mirena (Mirena),
  12. Postinor,
  13. Lactinet (Lactinette).

Important - the instructions for use of Yarin contraceptive pills, the price and reviews to analogues do not apply and can not be used as a guide for the use of drugs of similar composition or action. All therapeutic appointments should be done by a doctor. When replacing Yarin with an analogue, it is important to get expert advice, you may need to change the course of therapy, dosages, etc. Do not self-medicate!

Before taking any drugs on their own, while taking Yarin in parallel, you need to consult with your doctor or gynecologist. Before you start using Yarina, you should carefully analyze the family history and lifestyle of a woman, conduct an in-depth general medical and gynecological examination, incl. breast research and Papanicola test.

The need, volume and frequency of additional and control studies are determined individually. As a rule, check-ups are carried out once a year (more often if necessary).

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