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IVF: risks and features of the transfer of 2-3 embryos

I would not consider 1. I had transfers of 8, 3, 3 and 3 embryos - of all this, 2 times for 1 child, so the transfer of 2 or more embryos is not always equal to the multiple fetus. Although my friend got acclimatized triplets, twins and twins. Twins, even after the COP is quite real, there are examples in the environment, so that I, with my 2 CSs, if I decide on IVF, will carry 2-3.

Life is a supermarket. take what you want, but in the end you have to pay for everything.

Lera, Alexey (30/03/94), little princess Sophia (25/08/03) and juile 2010

Yes, they reported. The difference between the COP is over 7 years. I have a second KS with a difference of 8 years, the seam was absolutely trouble-free, it was Caesar at 40 weeks. She asked the doctor about the 3rd COP - said that it was quite possible, he had 8 practice sessions in his practice ..

There is always a risk, everyone decides for himself, no one will give guarantees even with the most favorable history. In general, after the first child (EP), doctors predicted that it was impossible to have more children, and still I don’t bear it (conization of the cervix, ICN and late miscarriage). I would like to show those doctors of two younger children.

Life is a supermarket. take what you want, but in the end you have to pay for everything.

Lera, Alexey (30/03/94), little princess Sophia (25/08/03) and juile 2010

+1 In IVF, in general, forecasts are ungrateful. I did IVF at 30 years old, with an excellent ovarian response, a large number of good embryos - and good luck only 3 times, although the doctor was sure that it would work out right away ..

When I was 36 years old, out of 20 UC only 3 embryos reached 5 days (2 bl and 1 morula), and it turned out 1 time :))

Life is a supermarket. take what you want, but in the end you have to pay for everything.

Lera, Alexey (30/03/94), little princess Sophia (25/08/03) and juile 2010

And again, so as not to be bored, several cases from practice:

Patient O., 34 years old, infertility 2, miscarriage, 4 IVF failures, at the patient’s high insistence and in the absence of absolute contraindications, I transferred 2 embryos (5AA, 3BB).

We had this ultrasound a few months ago:

Pregnancy was complicated by cervical insufficiency and suturing of the cervix in combination with obstetric pessary. Now the term is already big enough for triplets and we are waiting for the appearance of babies into the world (a boy and two girls).

And this is another patient of mine, E., 28 years old, the male factor of infertility, which of course listened to my recommendations and we transferred 1 embryo 5 days 4AA to the uterus.

Monochorial twins. Now they are torturing Mommy with strong toxicosis (And we wish them to grow and will be born in time!

Replanting 1 embryo odds. How and when are embryos transferred during IVF? Why only one embryo

When a woman decides on an in vitro fertilization procedure, she hopes to become a mother on the first attempt. Unfortunately, statistics states that pregnancy does not occur as often as we would like. Therefore, in order to play it safe, women are sometimes asked to transplant more embryos. For a better understanding of how many embryos are planted with eco, it is worth exploring the existing restrictions, recommendations and risks regarding this issue.

On the 3rd day of development, embryos consist of approximately 5-10 cells. On the third day, it is sometimes difficult to determine which embryos are likely to continue to develop until the next stage, called the blastocyst stage. While many embryos appear to usually develop under a microscope for 3 days after fertilization, some of them may linger in development and not develop further in a culture dish. On the other hand, embryos cultured outside the body grow in an artificial environment, and this also imposes tension on them.

It is possible that some of them would be successful in the natural environment of the uterus. Your doctor will discuss their individual recommendation regarding which stage to grow the embryos for in order to achieve an optimal result. This recommendation will often be made after we see how much and how well the embryos grow by the 2nd day or. When the embryos are ready to be transferred, they are placed in a thin tube, known as a catheter. Under ultrasound guidance, a catheter is inserted into the woman’s uterus and the embryo is transferred.

The essence of the process

In order to grow the embryo outside the uterus, as reproductionologists say, it is necessary to obtain female and male sex cells. Further, the scheme is carried out directly fertilization, cultivation of embryos and their transfer into the uterus. The success of a successful protocol depends on certain factors. In addition to the health of the woman herself, the quality of the transplanted material plays a huge part.

For this procedure, you need to have a full bladder. After embryo transfer, a woman is advised to avoid: stressful situations as much as possible, avoid anything that will significantly increase her body temperature, douching, and heavy lifting. Otherwise, it may resume normal activity after embryo transfer.

If the pregnancy test is positive, you should continue to take all the medicines until you tell us otherwise. During the first trimester, we will refer you to a midwife, family doctor, or midwife, who we can recommend or to someone of your choice. In some cases, if your pregnancy is considered a high risk, we recommend an obstetrician who specializes in high-risk pregnancies.

It is logical that a greater number of oocytes gives a greater chance of pregnancy. Normally, a woman matures 1-2 eggs per cycle without additional stimulation. During in vitro fertilization, ovarian function is activated using hormone injections to obtain a sufficient number of eggs. Since not all received cells will be of good quality, some will not fertilize, some will not divide and develop.

However, critics have stated that by reducing the number of embryos transferred, a group of women with a priori reduced probability of pregnancy are at a particularly greater risk of treatment. We wanted to study whether the practice of transferring three or more embryos would be of added value to these patients and whether the strategy of transferring heavy loads could increase the pregnancy rate to an acceptable level. This article sets out the proposed protocol within the legal framework relating to Belgium.

Key words: maternal advanced age, subfertility, heavy load transfer, embryo transfer, multiple pregnancies, never become pregnant. A fixed transfer of an embryo is defined as the transfer of one benign embryo when there are at least two well-known embryos.

How many eggs do you need for eco? It is a mistake to assume that the more eggs the better. According to statistics, when more than 20 follicles mature in superovulation, their quality is significantly reduced and the risk of ovarian hyperstimulation syndrome in a woman increases significantly.

However, fertility, defined as the ability to become pregnant, declines steadily with age for women. The gradual loss of the ability to become pregnant is a normal biological process that lasts up to ten years before the onset of menopause. In terms of fertility, women aged 35 years and older are considered women with advanced reproductive age.

The combination of declining fertility and deliberately delaying pregnancy has meant that a large group of women over the age of 35 could not get pregnant for twelve months. It has been shown that aging in women correlates with a poor ovarian response. In addition, the ability to develop embryos tends to decrease with age, due to both genetic factors and the lack of energy for the metabolically very active cellular mechanisms. Therefore, women of older reproductive age are considered patients with a poor prognosis.

In a situation where it is possible to get less than 5 eggs, the chances of getting a class A germ are reduced. The optimal number of eggs for a successful protocol 8-12. But this is individual, sometimes with 1-2 eggs, it is possible to grow healthy morula or blastocysts, which are successfully implanted.

How many embryos do you get with eco? The number of normally fertilized eggs and subsequently developed embryos cannot be accurately predicted. Mostly all doctors from experience say that, as a rule, from 50% to 90% of the collected oocytes will produce results.

The number of embryos obtained after stimulation and transmission also matters. Indeed, the number of live newborns in each age group increases with each subsequent embryo transfer. However, when transferring multiple embryos, the risk of multiple genera should be considered. Multiple pregnancies usually worsen the prognosis for mothers and babies, causing high costs for society.

In this population, a large number of transferred embryos correlate with the result. The literature confirms that a higher chance of pregnancy and childbirth in this particular subgroup of older women is achieved by increasing the number of transferred embryos. The data show that transferring four or more embryos has a positive effect: an increase in pregnancy rates without a significant effect on multiple pregnancy rates. This effect is observed only in women aged.

amount

The document that regulates the conduct of in vitro fertilization is the order of the Ministry of Health of the Russian Federation No 107n, dated August 30, 2012. According to his recommendations, 1 or 2 embryos are placed in the intrauterine system. Transfer 3 is allowed, but only with the voluntary written consent of the mother and the mandatory notification of the possible risks of such a decision.

Retrospective analysis of own data

In the group of women aged ≥ 42, fewer twins were observed. These women were chosen only by age, and women who have so many embryos obtained after stimulation do not actually have a poor prognosis. It is clear that a good patient choice is important. Our own retrospective study was based on data collected from the Department of Reproductive Medicine at the University of Ghent. The results are shown in the table in Figure 2 and in Table 3.

After 43 years, the chances of pregnancy are extremely low. In the group of younger than 40 years, there is an excess of singletons with a transfer of 3 embryos, and the transfer of 4 or more twin embryos is more common than single. We could doubt the power of this observance, because it is based on a low number of absolute numbers. After 40 years, there is an overweight of both singleton 3 and over 4 or more embryos. Threes did not occur in both age groups.

What day are embryos transferred to eco? It is believed that the cells that have grown in artificial medium up to 5 days after fertilization are stronger and give a good pregnancy rate.

In the case when the quality of the embryos does not correspond to the proper level, it is possible to transfer them to day 3.

In table 4, it is remarkable that the transfer of five embryos is not as successful as the transfer of three or four embryos. In a group of women younger than 36 years, there was no transfer of an embryo with five or more embryos. After 42 years, eight cycles occurred with the transfer of 5 embryos, none of them led to a live birth.

Recent clinical evidence suggests that the total number of embryos transferred, rather than the number of attempts, should provide guidance on stopping or continuing treatment. It includes both patients with a poor prognosis from the outset, and patients who, despite several “good” embryo transfers, have never thought about it.

In a woman's body, the chances of developing normally are greater. Replanting earlier than 5 days is possible even in a situation where the number of embryos with eco is less than 3-4, as the risk of cessation of their growth increases.

How does embryo transfer occur? The embryo grafting procedure is carried out in a medical institution. The whole process takes an average of 30 minutes. The doctor inserts a sterile catheter with embryos through the vagina, then through the cervix into the uterus. Most women do not experience significant discomfort during replanting.

For the other side of the clinical spectrum, no recommendations exist or they are rather vague. Inadequate treatment is a real risk in these patients. It has been shown that the transfer of several embryos in the elderly age group has a beneficial effect on pregnancy rates from the very beginning of treatment.

Patients included in the study may have a less poor prognosis. They reported that the analysis did not match the quality of the embryo and the previous failure of the cycle. Both studies reviewed and our own data are retrospective and purely descriptive. Only a large randomized trial can prove the usefulness of transferring many versus one or two embryos to patients with a poor prognosis. However, it is very difficult to conduct these tests ethically and technically because we are dealing with patients with a poor prognosis who may not want to be randomized to a group receiving one or two embryos and a group receiving at least three and up all the embryos.

Opinions of experts about how many embryos optimally fit a woman diverge. Some argue that there is no need to go against nature, which normally laid the ability to bear one fruit (the percentage of natural twins is very small). Others believe that transferring two embryos with eco increases the overall chances of pregnancy. There is also an opinion that inside the uterus the embryos somehow help each other, and when one stops, for the second implanted, the opportunity to develop normally increases.

Limiting the number of embryos to transfer to a maximum of two in all cases probably leads to an increase in this subpopulation. It will be difficult to prove; nevertheless, further research is needed to strengthen this conclusion. Petra de Sutter is the founder of a fundamental clinical study of the Flemish Foundation for Scientific Research.

The role of the number of replaced embryos on the result of intracytoplasmic sperm injection in women over the age The optimal number of embryos to be transferred to women over 40 years of age who are being treated with the help of reproductive technologies. Selective transmission of a single blastocyst reduces double rates without compromising pregnancy rates. Spindles, mitochondria and redox potential in aging oocytes. Reduction in the number of embryos transferred in Sweden - impact on childbirth and multiple fertility rates. There is something about the embryo transfer process, as well as some risks and precautions.

The doctors' reluctance to inject more than 2 fertilized oocytes is dictated by the risks of a multiple pregnancy. Bearing triple hard task. The risks that children will be born successfully and will not have pathologies increase by several times. The indication for the attachment of 3 embryos is the reduction (removal of "extra"). But this operation can harm all fruits without exception.

This article discusses how this process works, and who can benefit from embryo transfer. These eggs are then removed from the woman’s ovaries and fertilized in the laboratory. As fertilized eggs multiply, the embryos are transferred to the woman’s uterus. To begin a pregnancy, the embryo must attach itself to the wall of its uterus or womb.

When embryo transfer is needed

There are many reasons for embryo transfer, including. Ovulation Disorders: If ovulation is infrequent, fewer eggs are available for successful fertilization. Damage to the fallopian tubes: Fallopian tubes are the passage through which the embryos travel to reach the uterus. If the tubes are damaged or damaged, it is difficult for fertilized eggs to reach the uterus safely. Premature ovarian failure: if the ovaries do not pass, they do not produce a normal amount of estrogen or regularly release eggs. Uterine fibroids: fibromas are small, benign tumors on the walls of the uterus. They can affect the ability of the egg to plant itself in the uterus, preventing pregnancy Genetic disorders: it is known that some genetic disorders prevent pregnancy. Impaired sperm production: men have low sperm production, poor sperm movement, damage to the testes or sperm - all causes of natural fertilization can fail.

What to expect before, during and after embryo transfer

  • Endometriosis: when tissue from the uterus is implanted and grows outside the uterus.
  • This may affect the functioning of the female reproductive system.
Примерно за 2 или 3 дня до переноса эмбрионов врач выберет лучшие яйца для переноса в матку.

Рациональным будет прислушиваться к мнению опытного специалиста. Лечащий врач способен оценить сполна факторы, влияющие на определение количества переносимых зародышей – возраст пациентки, состояние здоровья, болезни в анамнезе и прочие. Поэтому лучше подсаживать эмбрионов при эко столько, сколько будет рекомендовать доктор.

Unfortunately, it is not always possible to get pregnant with ART using the first time. Waiting for the re-eco, if such a decision was made, for a woman is a difficult test. But, mostly successful protocols are obtained from the second or third attempt. To feel the joy of motherhood is worth trying several times.

The most crucial stage of in vitro fertilization is the transfer of embryos into the uterus. Many discussions and experiences of future parents are connected with this. Everyone is concerned about the main question: how many embryos are better to plant in IVF? Some believe that it is optimal to transfer 1 embryo, others - 2 or more. In this situation, first of all, the woman should trust the fertility specialist. The doctor, taking into account the individual characteristics of the female body, will help make the right choice.

Preparing for embryo transfer with IVF

Before implantation occurs, the expectant mother must undergo an appropriate examination. If any abnormalities are found, the first step is treatment. It should also fill the required level of hormones. Favorable hormonal background creates a prerequisite for endometrial growth, which greatly increases the chances of embryo engraftment and successful pregnancy.

Cryopreservation of embryos and ova during IVF

What day are embryos transferred to eco? It is believed that the cells that have grown in artificial medium up to 5 days after fertilization are stronger and give a good pregnancy rate.

In the case when the quality of the embryos does not correspond to the proper level, it is possible to transfer them to day 3.

In a woman's body, the chances of developing normally are greater. Replanting earlier than 5 days is possible even in a situation where the number of embryos with eco is less than 3-4, as the risk of cessation of the growth of them all increases.

How does embryo transfer occur? The embryo grafting procedure is carried out in a medical institution. The whole process takes an average of 30 minutes. The doctor inserts a sterile catheter with embryos through the vagina, then through the cervix into the uterus. Most women do not experience significant discomfort during replanting.

Opinions of experts about how many embryos optimally fit a woman diverge. Some argue that there is no need.

Almost all stages of artificial insemination behind. There remains the last, final chord of IVF - embryo transfer. How does the process of embryo transfer occur? What day is optimal for replanting? Consider in detail.

By the way, in this article you can find out how the selection of the best quality embryos for transfer occurs and which classifications are used for three days and blastocysts.

There are several types of replanting in vitro fertilization:

Standard, double, combined.

On which day will embryo transfer be optimal?

Planting is carried out from 2 to 6 days from the start of cultivation. The scatter in the timing is 5 days. Why is that?

This is due to a number of circumstances:

If they are 4–5, then it is rather difficult to choose the best on the second or third day of cultivation. Therefore, prolonged cultivation is a kind of test of time and a test of viability. Today, the embryo can be of excellent quality, in a day -.

I came to the doctor on eco with the words that I want to be pregnant with one child so that it is easy to wear. She recommended me to plant 1 embryo. Did not work out.

On the second attempt, they decided to plant 2 embryos. I already think, well, there will be twins like twins. Again, no!

Now I am preparing for the third protocol. Only 3 of the frozen embryos are left. The doctor recommends planting all 3 to increase the chances. And here I am in doubt. What if all 3 take root? And what nurture triple? These are big risks!

Only 2 embryos can be planted, but it is not very convenient for me, since I live in Russia, and I do eco in the United States. Firstly, for the sake of one embryo you don’t rage, and secondly, if I’m going to fly, then only half a year later. And precious time is a pity. And so it will be old-aged.

In this regard, I have many questions for you. Please share your thoughts and experiences.

Embryo replanting with IVF in the uterine cavity is the last and most exciting stage of the protocol. On average, the procedure ends in success in 35-40% of cases. Find out whether she got into this happy percentage a woman can only after 10 days. All this time, her body will conduct a “dialogue” with the embryo, as a result of which he can either successfully implant into the uterine endometrium, or be forced to leave with blood during the next menstruation.

Even in the natural conception, the rejection of fertilized eggs occurs much more often than a woman might suspect. A significant part of embryos conceived by an absolutely healthy young couple are genetically deficient - the uterus will not give them a chance to live and reject. Under natural conditions, only 30% of conceptions end in pregnancy, and from this point of view, the effectiveness of IVF does not seem so low.

How and when are embryos transferred during IVF?

If a woman can not get pregnant.

Hello! My name is Elena Kuznetsova @kuzyamihailovna. I am an obstetrician-gynecologist, reproductologist, candidate of medical sciences and head of the IVF clinic of the Mother and Child Ryazan Clinic. In my last article, I described the process of preparing for IVF, and now I will introduce you to the main points of preparation for the procedure.

How often do we, fertility specialists, hear from our patients: “I want twins”, “Please transfer 2 or 3 embryos to me”, “I'm afraid not to get pregnant while transferring one embryo”, “My friend in another clinic transferred 3 embryos, and she got pregnant, I also want so. "

And today I would like to talk about the indications, contraindications, risks and features of the transfer of 2-3 embryos.

We will talk about embryo transfer at the blastocyst stage (5-6 days of development), since at this stage the implantation potential of the embryo is higher than in the early stages of 1-4 days. So it is shown that the early embryo of good quality, demonstrating even logical.

Yes, they reported. The difference between the COP is over 7 years. I have a second KS with a difference of 8 years, the seam was absolutely trouble-free, it was Caesar at 40 weeks. She asked the doctor about the 3rd COP - said that it was quite possible, he had 8 practice sessions in his practice ..

There is always a risk, everyone decides for himself, no one will give guarantees even with the most favorable history. In general, after the first child (EP), doctors predicted that it was impossible to have more children, and still I don’t bear it (conization of the cervix, ICN and late miscarriage). I would like to show those doctors of two younger children.

Life is a supermarket. take what you want, but in the end you have to pay for everything.

IVF ICSI - all about the modern method of fertilization

When a couple really wants a child, and a woman cannot become pregnant for a long time naturally, the family begins to try artificial methods. One of such methods is ECO ICSI (ICSI). This is an in vitro fertilization using an intracytoplasmic injection.

IVF plus ICSI - what is it?

IVF in vitro fertilization is a process in which eggs and spermatozoa are placed in the same container. In this environment, conception occurs in a “natural” way. But IVF using the ICSI method is carried out with pronounced disorders and deviations from the norm in men. It is possible with one morphologically normal and viable tadpole.

Answering the popular question of what ECO ICSI is, how the process itself takes place, it should be said that this procedure is performed artificially under a microscope. The embryologist selects 1 sperm and using special microtools (needles and suckers.

You can find out the answer to the question, on which day it is better to plant embryos during IVF, at a consultation with an embryologist. The decision on podsazhivaniya time is based on the quantitative and qualitative component of the embryo and depends on the number of previous unsuccessful attempts in vitro fertilization.

Stages of development of zygotes outside the maternal organism

Considering the stage of development of the embryo, we can conclude on what day it is better to sit down the embryos during IVF.

0 day - collecting eggs, fertilizing them with sperm. In medical practice, it is considered to be zero.

1 day - fertilization is evaluated. If two nuclei are detected in the egg, then the process was successful.

Day 2 - the embryo begins to divide into blastomeres (daughter cells). At this stage, the number.

Embryo replanting is performed on 3-5 days after ovulation, because in the natural menstrual cycle it is at this time that the endometrium is ready to receive a fertilized egg, this is called implantation. But women with IVF are usually given 3 or 5 day old embryos. Let's consider what it is connected with, and which embryos take root 3 or 5 days better?

With controlled ovulation, after the egg is collected, it is fertilized and grown on special media to check how good the quality of the resulting zygotes is. The fact is that more than 50% of the eggs, even in a young woman, have pathology. Observation of how the division of the egg, allows you to identify anomalous forms at an early stage.

So, by the third day of cultivation on a nutrient medium, the zygote must contain at least 6 cells, the slowing down of this process indicates the poor quality of the fertilized egg. Of course, the reason for this may be improper nutrition.

Read the real story of how embryo transfer occurs to the uterine cavity, what sensations a woman experiences, whether anesthesia is used, and recommendations for post-transfer, which can be successful in the protocol.

How to prepare for embryo transfer

As the doctor recommended to me, I passed the Utrozhestan course in advance. This is necessary in order to make the flora of the uterus conducive to anchorage on its walls of the ovum. Utrozestan is a hormone of the corpus luteum - a gestagen - which in vivo is produced in women during ovulation. Because in vitro fertilization is.

1 Tube embryo development before transfer

Video about in vitro embryo development before transfer

The zygotes obtained after fertilization are placed in a special environment (test tube), where experienced embryology specialists carefully observe the whole process of embryo development, which at the age of 3–5 days is placed in a special way into the uterus of a woman, where, in case of successful implantation, their further intrauterine development goes normal. by. About how the transfer of embryos from the test tube into the woman's body and how many of them are planted, will be described in detail in this article.

After the oocytes obtained from the woman’s body in a short or long protocol have been artificially fertilized, their test-tube cultivation begins. Fertilized eggs are just one cell (zygote), which after 9 months will have to become a little man, but at this stage of its development, it only has a set inherited from her mom and dad.

Why ABA-PETER

World-class high-tech IVF medical center . The first reproductology clinic in Russia that has been certified under the international quality assessment system ISO 9001: 2008. The clinic is equipped with the highest quality modern medical equipment that meets all modern standards and requirements.

Vast experience, more than 15 years in the field of reproductive technologies. Many of the specialists were trained in leading European IVF clinics. Specialists of the clinic are regular participants of international and Russian conferences on infertility treatment.

High efficiency ongoing programs of ART (performance)

You can make an appointment and ask questions by phone 8 (812) 600-77-78

Divorced - it happens

Yes, and for parents and doctors this is often a surprise. You transfer one embryo, at the exit twins. Bearing two - triplets. These cases are not so rare - about 1-2 per hundred transfers, and it is not always possible to predict them. Two fetal eggs can be obtained from the blastocyst at the stage of "hatching" from the shell of pellucida - and this stage occurs already in the uterus.

This winter, "The Test Tube" has already talked about the British couple Field and Karl Crozier, waiting chevernyashek. Pregnancy occurred after several unsuccessful IVF attempts. Both transferred embryos unexpectedly formed four fetal eggs at once. By the way, as it turned out - all the girls. The pair refused the reduction proposed by the doctors. At the time of publication of the news, Karl was five months pregnant.

A member of one of the ECO-forums has a unique rare occurrence - a quadruple of one embryo has turned out. Unfortunately, that pregnancy could not be reported. The next time Kira was also transferred one embryo, and a few days ago she gave birth to her long-awaited son, with which we congratulate her.

Elissa Ovcharuk, fertility specialist, “Center of ECO” Kaluga

For women who decide to have an IVF pregnancy, the time between puncture and transfer is very exciting. The number of embryos for transfer is determined by the fertility specialist, taking into account the state of the patient. It is recommended to transfer into the uterus no more than two embryos of only good quality, provided that the endometrium is fully mature. In order to avoid multiple pregnancies in good endometrial condition and high quality embryos, one embryo is transferred.

If there are symptoms of ovarian hyperstimulation, a single embryo is transferred or the transfer is postponed altogether - as the pregnancy aggravates the development of the HFG syndrome. If the endometrial thickness does not correspond to the “window of implantation” period, the transfer process is postponed and the endometrium is prepared, namely, synchronization between the uterine and ovarian cycle with the help of hormone therapy.

The most important and interesting news about the treatment of infertility and IVF now in our Telegram channel @probirka_forum Join us!

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