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Pyrogenal (candles / injections): instructions for use, analogues and reviews

In this article, you can read the instructions for use of the drug. Pyrogenal. Presented reviews of visitors to the site - the consumers of this medicine, as well as the opinions of medical specialists on the use of Pyrogenal in their practice. A big request to add your feedback on the drug more actively: the medicine helped or did not help to get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Pyrogenal analogues in the presence of available structural analogues. Use for the treatment of adhesions, uveitis and chronic prostatitis in adults, children, as well as during pregnancy and lactation.

Pyrogenal - broad-spectrum immunomodulator, activates reticuloendothelial, hypothalamic-pituitary and fibrinolytic systems. It has desensitizing and anti-inflammatory properties, increases the general and specific resistance of the body, affects the hypothalamus thermoregulatory centers.

Composition

Lipopolysahard isolated from Salmonella typhi bacteria + excipients.

Indications

  • CNS and peripheral nervous system injuries,
  • tuberculosis (torpid form in the phase of resorption),
  • chronic liver disease,
  • strictures of the urethra, ureters, chronic prostatitis, urethritis,
  • uveitis, iridocyclitis, herpes infection of the eye, corneal clouding,
  • inflammation of the uterus, infertility,
  • adhesive disease of the abdominal cavity,
  • burn disease
  • venereal diseases,
  • psoriasis and other chronic skin diseases,
  • specific provocation during examination for sexually transmitted diseases,
  • for pyrotherapy.

Forms of release

Solution for intramuscular injection (pricks in ampoules for injections).

Candles for rectal use 50 µg, 100 µg, 150 µg and 200 µg in packs of 5, 10 and 12 pieces.

Other dosage forms, whether tablets or syrup, are not registered.

Instructions for use and dosage

Intramuscularly 1 time per day every other day, if necessary, the drug is diluted with 0.9% sodium chloride solution.

The initial single dose is 0.2 mcg, in the following days the dose is gradually increased by 2.5-5 mcg.

The maximum single dose - 100 mg. Full course - 10-30 injections, if necessary, a course can be repeated in 2-3 months.

For pyrotherapy - intramuscularly 1 time per day, starting from 5-10 μg with an increased dose increase to 100-150 μg. Injections are carried out in 1-2 days.

Rectal, 1 suppository per day, every day or every other day, initial dose - 50 mcg, maximum dose - 200 mcg. The course of treatment is 12-15 suppositories. The recommended treatment is as follows: 50, 50, 50, 100, 100, 100, 150, 150, 150, 200, 200, 200 μg. When using suppositories in the form of monotherapy for immunorehabilitation with incomplete recovery from acute bacterial or viral disease, suppositories of 50 or 100 μg should be used. The course of treatment is 5-10 suppositories.

Simultaneous treatment with suppositories and intramuscular injections is possible.

Course Treatment Pyrogenal

Injections: Starting with 5 μg / ml every other day in an incremental rate in increments of 5 μg / ml - 15-20 injections. The maximum single dose - 150 mg / ml.

Candles: Course 10-12 days, incremental, daily. Or a set of 12 suppositories, or, according to the scheme:

Pyrogenal 50 µg - 3 days + Pyrogenal 100 µg - 3 days + Pyrogenal 100 µg + Pyrogenal 50 µg - 3 days + Pyrogenal 100 µg - 2-3 days = 12 days.

In a chronic process, a course of 24 days - Pyrogenal 50 mcg - 6 days + Pyrogenal 100 mcg - 6 days + Pyrogenal 100 mcg + Pyrogenal 50 mcg - 6 days + Pyrogenal 100 mcg - 2-6 days = 24 days.

Side effect

  • increase in body temperature to 37.5 ° С
  • chills,
  • malaise,
  • headache,
  • back pain.

Contraindications

  • acute febrile illness
  • chronic diseases in the stage of exacerbation and decompensation (with the exception of diseases that are indications for prescribing the drug),
  • blood diseases
  • pregnancy.

Use during pregnancy and lactation

Contraindicated in pregnancy.

Use in children

In children, the dose is reduced in accordance with age, starting with the introduction of 5-15 IU, gradually increasing the dose, if necessary, but not exceeding 250-500 IU. In the course of treatment - 10-15 injections.

special instructions

If intramuscular administration usually causes hyperthermia, chills, or discomfort within 3–8 hours, the dosage that caused this reaction is repeated on subsequent days (usually 1–3 days) until the reaction stops, after which the dose is subsequently increased.

If within 6-8 hours hyperthermia occurs to 39.5 ° C, severe chills, headache, back pain, it is recommended to reduce the dose of the drug. When using the drug for pyrotherapy, the above reactions are permissible.

In the presence of convulsive readiness, the drug is prescribed on the background of anticonvulsant therapy.

Drug interaction

The drug is compatible and well combined with all drugs used in the treatment of diseases and conditions indicated in the indications. Enhances the effectiveness of chemotherapeutic drugs as part of complex therapy.

Analogues of the drug Pyrogenal

Structural analogues of the active substance drug Pyrogenal has not.

Analogs on the therapeutic effect (means for the treatment of adhesions):

Indications for use

What helps Pyrogenal? According to the instructions, the drug is prescribed in the following cases:

  • Chronic liver disease,
  • Burn disease
  • Strictures of the ureters and urethra,
  • Adhesive disease of the abdominal cavity,
  • Prostatitis and urethritis in a chronic course,
  • Venereal diseases,
  • Secondary infertility
  • Diseases of the uterus inflammatory etiology.

  • Human papillomavirus infection
  • Incomplete recovery after acute viral and bacterial diseases (immunorehabilitation and immunoprophylaxis).

Pyrogenal injections (optional):

  • Traumatic injuries of the peripheral and central nervous system,
  • Herpes infection of the eye,
  • Slow tuberculosis in the resorption phase,
  • Chronic skin diseases, including psoriasis,
  • Iridocyclitis
  • Corneal opacity,
  • Uveitis,
  • The need for pyrotherapy (as a pyrogenic drug).

Instructions for use Pyrogenal dosage

Intramuscularly 1 time per day every other day, if necessary, the drug is diluted with 0.9% sodium chloride solution.

The initial single dose is 0.2 mcg, in the following days the dose is gradually increased by 2.5-5 mcg.

  • The maximum single dose - 100 mg.
  • Full course - 10-30 injections, if necessary, a course can be repeated in 2-3 months.

Instructions for use Pyrogenal recommends the following dosages for pyrotherapy sessions - intramuscularly 1 time per day, starting from 5-10 mcg with an increased dose increase to 100-150 mcg. Injections are carried out in 1-2 days.

Pyrogenal Candles

According to the instructions, candles are inserted rectally in 1 suppository per day. The drug is applied daily or every other day.

  • The initial dose is 50 mcg,
  • Maximum allowable - 200 mcg.
  • Duration of therapy - 12-15 candles.

The following scheme is used for treatment: the initial dose is 50 µg, and then every 3 days a 50 µg increase is performed.

If suppositories are used as monotherapy, suppositories are prescribed at 50 or 100 micrograms. The course of therapy is 5-10 suppositories.

Simultaneous use of Pyrogenal plugs and intramuscular injections is acceptable.

Side effects

The instruction warns about the possibility of the development of the following side effects in the appointment of Pyrogenal:

  • Increased body temperature to 37.5 ° C), chills, malaise,
  • Rarely - hyperthermia (up to 39.5 ° C), severe chills, headache, back pain.

The described reactions when used for pyrotherapy are allowed.

Contraindications

It is contraindicated to appoint Pyrogenal in the following cases:

  • acute febrile illness
  • chronic diseases in the stage of exacerbation and decompensation, with the exception of diseases that are indications for the appointment of pyrogenal,
  • blood diseases
  • pregnancy and lactation.

People suffering from chronic diseases of the cardiovascular system, kidney and diabetes should be treated under the supervision of a physician.

In the presence of convulsive readiness or febrile convulsions in the history of the drug or not prescribed, or administered with anticonvulsant therapy.

Children under 5 years of age and patients over 60 years old should be given a reduced dose of Pyrogenal Injection. Its increase is possible only under the supervision of a specialist and with good tolerability of the drug.

Overdose

Data overdose available. Possible increased side effects.

Analogs Pyrogenal, price in pharmacies

If necessary, it is possible to replace Pyrogenal with an analogue for therapeutic action - these are drugs:

Matches for ATH code:

Choosing analogues it is important to understand that the instructions for use of Pyrogenal, price and reviews, do not apply to drugs of similar action. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in Russian pharmacies: Pyrogenal injection solution 10 µg / ml 1 ml 10 ampoules - from 797 to 1100 rubles, 50 µg / ml solution 1 ml 10 ampoules - from 730 to 1021 rubles, the price of Pyrogenal solution is 25 µg / ml 1 ml 10 pcs. - from 780 rubles, according to 783 pharmacies.

Store in a dark place at a temperature of 2 ... 10 ° C. Keep out of the reach of children. Shelf life - 2 years. The preparation in the opened ampoule is not subject to storage.

Conditions of sale from pharmacies - prescription.

Drug pyrogenal

Pyrogenalimmunomodulator bacterial origin, having a wide spectrum of action. Its active substance is bacterial lipopolysaccharide, which is obtained from the microbial mass of gram-negative cultures.

Pyrogenal has many properties:

  • desensitizing (anti-allergic),
  • anti-inflammatory,
  • regenerating
  • adjustable pyrogenic (increases the body temperature by 1-2 o for 2-4 hours, affecting the thermostatic center in the hypothalamus),
  • specific and general immunostimulating (increases the general resistance of the organism to infections),
  • stimulates the activity of the adrenal glands, resulting in increased concentration of corticosteroid hormones in the blood,
  • increases the permeability of tissues, capillary walls and the blood-brain barrier, resulting in improved metabolic processes,
  • accelerates the processes of regeneration (recovery) of nervous tissue,
  • facilitates the penetration of antibiotics and other chemotherapeutic drugs into the focus of inflammation,
  • restores blood circulation in the affected tissues and organs,
  • prevents the formation of adhesions and scars, as well as smoothes existing post-traumatic skin defects,
  • improves the fibrinolytic (anticoagulant) properties of blood,
  • helps to restore the lost functions of organs.

Leukopenia (decrease in the number of leukocytes) occurs in the blood after Pyrogen administration, which is followed by leukocytosis (increase in the level of leukocytes).

After introduction into the body, the main part (up to 90%) of Pyrogenal accumulates on the surface of leukocytes, and only 10% circulates freely in the blood.

The drug is derived only by the kidneys.

Contraindications

  • Hypersensitivity to the main active ingredient or auxiliary components of the drug,
  • cardiovascular failure
  • kidney and liver failure
  • pregnancy and lactation,
  • a history of autoimmune diseases
  • acute diseases with a large rise in temperature,
  • blood diseases
  • chronic diseases in the period of exacerbation or in the stage of decompensation (exception - diseases that are indications for prescribing medications).

Pyrogenal is prescribed with caution in diabetes mellitus, cardiovascular diseases, kidney diseases and convulsions of various etiologies.

Pyrogenal treatment

How to apply Pyrogenal?
Pyrogenal, depending on the form of release can be applied rectally in the form of candles or injections. The choice of route of administration, dose and treatment regimen depends on the main diagnosis.

The doctor individually selects for each patient the minimum dose of Pyrogenal, which causes a rise in temperature. This dose is administered until the temperature stops rising after the injection or the injection of a candle. As soon as this occurs, the dose begins to increase.

In treatment with Pyrogenal, due to the high probability of side effects, one should refrain from managing transport, complex mechanisms and other dangerous activities that require increased attention and quick response.

Pyrogenal is prescribed to children infrequently and with caution due to the lack of reliable data on the results of treatment.

Patients prone to febrile convulsions or with convulsive readiness, Pyrogenal is prescribed under the guise of anticonvulsant therapy and only in stationary conditions.

Pyrogenal Dosage
Suppositories
Candles are administered rectally once a day, every day or every other day, depending on the doctor's prescription. The minimum single dose - 50 mg, the maximum - 200 mg.

Treatment with suppositories most often takes place according to such a scheme, in which the course requires 12 suppositories - 3 for 50 mcg each, 3 for each 100 mcg, 3 for each 150 mcg and 3 for each 200 mcg.

But sometimes the scheme and course of treatment can be individual and different from the standard ones.

In case of protracted acute processes of bacterial or viral etiology or frequent relapses of acute respiratory infections, Pyrogenal is prescribed as an immunomodulator in the form of rectal suppositories of 50 µg or 100 µg. The course of therapy in this case is from 5 to 10 suppositories.

Solution for intramuscular injection
Injections do once a day every other day. Sometimes Pyrogenal is diluted with a 0.9% sodium chloride solution before administration. An open ampoule with a solution cannot be stored.

The dose of the drug at the first injection of the minimum - 2.5 mg. But in the course of therapy, it is gradually increased by 2.5-5 μg and adjusted to a maximum of 100 μg. The course of treatment is from 10 to 30 injections. If necessary, it can be repeated, but not earlier than in 2-3 months.

In pyrotherapy, Pyrogenal is prescribed in a dose of 5 to 10 μg and administered intramuscularly 1 time per day. This dose is gradually increased to 100 -150 mcg. The interval between injections is 1 - 2 days.

Doctors sometimes practice combination treatment, in which the injections alternate with the administration of suppositories.

Pyrogenal and alcohol

According to the observations of practitioners, Pyrogenal has the ability to arrest the binges and hangover in 96-98% of cases. Therefore, in case of alcoholism, Pyrogenal is prescribed to reduce the craving (pathological craving) for alcohol in the first days of treatment by artificially raising the temperature.

In this case, the drug is administered for five days according to a special scheme with a gradual increase in dosage: 50 μg - 75 μg - 100 mg - 125 μg - 150 μg per day. After two or three hours, the body temperature rises to 38-39 o С and again normalizes during the day.

If the treatment of alcoholism is carried out on an outpatient basis, the maximum dose of Pyrogenal should not exceed 100 mg per day.

Pyrogenal in gynecology

The main indications for the use of Pyrogenal in gynecological practice include the following:

  • secondary infertility
  • sexually transmitted diseases - syphilis, trichomoniasis, gonorrhea, etc.,
  • inflammation of the uterus,
  • human papillomavirus infection.

In gynecology, pyrogenic is also used in pyrotherapy and for provocation of latent infectious diseases in women.

Pyrogenal suppresses Trichomonas (pathogens of trichomoniasis) and Giardia at the cellular level, and promotes regenerative processes in the tissues affected by the pathogens.

In the treatment of sexually transmitted diseases, Pyrogenal consistently fights with each new wave of the pathogen, and also helps chemical preparations penetrate into the focus of inflammation and completely destroy microorganisms.

The drug is effective in combating gonococci, chlamydia, trichomonads and Giardia.

Provocation Pyrogenal

Sometimes venereal diseases (in particular, gonorrhea) may be asymptomatic. The patient carrier of the pathogen infects all its sexual partners, often without knowing it.

Pyrogenic provocation is used to identify hidden genital infections in the human body that are asymptomatic, to clarify the diagnosis and monitor the effectiveness of the treatment.

With provocation, Pyrogenal is administered intramuscularly, in parallel with the vaccine vaccine.

The purpose of the provocation is to cause an exacerbation of the disease by artificially induced decrease in immunity and at the same time increase the viability of the pathogens of the disease.

Drug reviews

Concerning Pyrogenal, the opinions of patients and doctors do not always coincide. Reviews of doctors about the drug are positive, because provocation by Pyrogenal contributes to the rapid refinement of the diagnosis and timely start of treatment.

Patients quite often speak negatively of Pyrogenal, noting the pronounced soreness of the injections. And many of them are simply not ready for side effects in the form of temperature and malaise, which manifest themselves in the first hours after the administration of the drug. However, the therapeutic effect of Pyrogenal in the reviews is not subject to criticism.

Drug price

Pyrogenal is produced by several enterprises in Russia.

  • Pyrogenal in the solution for injection of 10 µg / ml costs from 303 to 468 rubles.
  • Pyrogenal in the solution for injection 25 µg / ml costs from 329 to 457 rubles.
  • Pyrogenal in the solution for injection 50 μg / ml costs from 410 to 510 rubles.
  • Pyrogenal in solution for injection 100 μg / ml costs from 400 to 567 rubles.

  • Pyrogenal candles 50 mcg cost from 524 to 613 rubles. per pack.
  • Pyrogenal candles 100 mcg cost from 449 to 980 rubles. per pack.
  • Pyrogene candles set (12 candles) costs from 793 to 923 rubles.

Release form

Suppositories, characterized by white or yellowish color, with a diameter of 10 mm. with a pointed end of a cylindrical shape and a uniform consistency, they are produced in special packages (contour cells) in a set of 3 pcs. dosage of 50 mgk., 3 pcs. - 100 mgk., 3 pcs. - 150 mgk., As well as 3 pcs. - 200 mgk each. As a result, in one cardboard package of Pyrogenal there is a set of candles (12 pcs.).

The solution intended for injections is packaged in special ampoules. In one carton of the drug is 10 ampoules of 1 ml. solution in each.

Pharmacodynamics and pharmacokinetics

This drug belongs to immunomodulatorsthat have a wide spectrum of action. Pyrogenal compounds have an effect onhypothalamus, to the adrenal cortex, andon the pituitary gland.In addition, the drug affects fibrinolytic, and reticuloendothelial system.

LPS raise the level blood corticosteroidsand also affects the work adrenal cortexincreases resistance and changeshypothalamic thermostatic centersthereby creating pyrogenic effectwhich can be controlled. The drug interacts with phagocytic system thus starting the process synthesis of IL-2, and IL-1, oxygen radical secretionand IFNa (interferon).

Pyrogenal is involved in stimulating body kinin systemobstructs collagen fibroblast synthesis and accelerates ripening fibroblasts. Thanks hyaluronidosis stimulationas well as reducing production collagen fibers This medicine enhances tissue permeability, improves as a result. blood fibrinolytic propertiesand increases the rate of propagation of active compounds in the body.

The drug helps speed up the resorption process of previously formed scar in the lesions and also impedes the process of education adhesions. In addition, the drug compound has regenerating properties and helps in restoring the wound of lost body functions.

Side effects

With the use of rectal suppositories, Pyrogenal may increase the temperature of the body to a maximum of 37.6 C, as well as manifest primary symptoms. influenza (fatigue, chills, nausea, fever, arthralgia, headaches and myalgia).

When using a medicinal solution for injection, the same side effects can occur, and back pain can also occur and the body temperature can rise to 39.5 C. It is worth noting that the above side effects of the drug are quite acceptable when using it during pyrotherapy.

Pyrogenal injections, instructions for use (method and dosage)

Intramuscular injections Pyrogenal make after one day, one injection per day. For the preparation of a medicinal solution, the drug is mixed with sodium chloride.The course of therapeutic treatment begins with a dose of 2.5 mgc., And then gradually increasing each day by a maximum of 5 mgc. The maximum permissible single dosage of the drug does not exceed 100 mgk.

As a rule, the course of treatment is limited to 10-30 injections. Repeated injections begin to use after not less than two months since the previous course of treatment. This drug release form is used in pyrotherapyat a dosage of 10-25 mg. with a gradual increase to 150 mgk. Usually, injections are performed after 1 or 2 days.

According to the instructions for Pyrogenal, candles are used rectally, one suppository per day in a dosage of 50 μg. The maximum dosage of the drug is 200 mcc. per day. Patients are recommended to use the following drug treatment regimen - suppositories are administered three times a day rectally at a dosage of 50, 100, 150, or 120 mgc.

As a rule, approximately 12 Pyrogenal candles are consumed per treatment. Suppositories are often used for immunorehabilitation, and immunoprophylactic treatment in the recovery period after acute viral and bacterial diseases at a dosage of 50 or 100 mgc. Typically, the course of such treatment is limited to a maximum of 10 candles.

Candles and injections of Pyrogenal can be combined.

Interaction

Pyrogenal can be combined with drugs that are used in the treatment of the above indications for the use of this drug. However, it is worth remembering that this medicine as part of complex therapy may enhance the effectiveness of chemotherapeutic agents.

During pregnancy and lactation

The drug is contraindicated duringof pregnancyso in the period lactation.

With normal tolerance, Pyrogenal can be used in the treatment of children under the age of 5 years; however, the drug should be administered in reduced doses and only under the supervision of a physician.

Medicinal properties

Pyrogenal has a number of reducing properties. Improves the work of the central nervous system and ANS, enhances the body's defenses and launches its compensatory capabilities.

Pyrogenal treatment shows a good interaction with other drugs. To obtain the maximum effect, it is necessary to construct a treatment regimen.

Consult your doctor and help you find the right dosage.

One of the most common methods of application is the fight against alcohol. When attempting to bind with alcohol, Pyrogenal is prescribed, using its pyrogenic properties, is able to stop hard drinking and hangover conditions at the initial stage of treatment, by artificially raising the temperature.

During an elevated temperature, the person completely disappears the desire to take alcohol.

It is applied within 5 days, corresponding to the special scheme with gradual increase in a dosage.

Another popular application is pyrotherapy.

Pyrotherapy - treatment by increasing body temperature by introducing pyrogenic substances into the body. The use of pyrotherapy is accompanied by the following positive effects:

  • Blood circulation improvement
  • Metabolism improvement
  • Normalization of the CNS and ANS
  • Improving the immunobiological response of the body.

Forms of release

The cost of Pyrogenal in ampoules ranges from 300 to 500 rubles.

The drug has two main forms of manufacture:

  • Rectal candles - are available in one package of 5 or 10 pieces with a diameter of up to 1 cm of the same concentration. There are also types of release of 5 pieces of different concentrations, and a set of 12 pieces of different concentrations.
  • Ampoules with intramuscular injection - sold in packs of 10 ampoules of the same concentration. Each ampoule is 1 ml.

About Pyrogenal formed a rather contradictory opinion. Doctors are happy with the drug and recommend it in most cases.

The cost of candles ranges from 400 to 900 rubles.

People who were treated with pyrogenal, left negative reviews about the drug. The reason for such reviews were frequent side effects that caused severe fatigue and fever.

Most reviews are written like this: “I put candles to my husband, pyrogenal, after which he had a very high temperature, and a headache. I do not recommend. To avoid such situations, you must carefully read the instructions.

Mode of application

The solution for injections is administered intramuscularly or intravenously. For every person. The treatment scheme is built for each person individually, depending on:

  • Condition of the patient
  • Age
  • Drug susceptibility
  • Disease

Injections are given daily, once a day. The dose of the drug is set in a certain way. First you need to enter 25-50 MCG and wait until the body temperature starts to rise to 37.6-38 ° C. As soon as the temperature stops rising, the dose of the medicine is increased by 25-50 mcg. After use, the vial must be discarded.

The maximum value of a single use of pyrogenal for adults is 1000 MCH. The maximum dose for children is significantly reduced depending on age, starting at 5–15 ICG, increasing as necessary up to a limit of 250–500 ICG.

The course of treatment is built on 10-30 injections. At the recommendation of the doctor will need to undergo a course again. Re-treatment is possible only after a break of 2-3 months.

Suppositories - In this form, the drug is administered rectally. The initial dose is 50 mcg and, in the absence of a strict prescription, gradually increases to 200 mcg.

If pyrogenic suppositories are used as immunoprophylaxis or immunorehabilitation, then 50-100 mcg will be enough.

It is possible to put suppositories both in the afternoon, and at night. However, doctors recommend to install better at night when the body is as long as possible in a fixed state.

Prodigiosan

Available in the form of a solution for injection intramuscularly 0.005% and 0.01% with the content of sodium chloride. The drug promotes regenerative processes, activates the body's protective reserves and normalizes the tone of blood vessels at the site of inflammation.

Pros: improves immunity, speeds up recovery after surgery, relieves inflammation and swelling.

Minuses: Quite often, side effects similar to pyrogenale are manifested. The drug is almost impossible to get.

Registration for it in Russia was canceled in 1977.

Pharmacokinetics

After the introduction of the drug, the substance is fixed on the surface of circulating blood leukocytes (up to 85–90% of the dose). Approximately 10% remains in the circulating plasma and approximately 5% is adsorbed on the erythrocyte membranes.

With the introduction of Pyrogenal in the latent period (45 to 90 minutes), leukopenia develops, which is later replaced by leukocytosis, which lasts for 24–48 hours.

From the body the drug is excreted in the urine.

All dosage forms

  • Chronic liver disease,
  • Burn disease
  • Strictures of the ureters and urethra,
  • Adhesive disease of the abdominal cavity,
  • Prostatitis and urethritis in a chronic course,
  • Venereal diseases,
  • Secondary infertility
  • Diseases of the uterus inflammatory etiology.

Composition and release form

Pyrogenal has two dosage forms - suppositories for rectal administration and solution for intramuscular administration. Each carton pack contains instructions for use:

  1. Yellow, cylindrical suppositories with a pointed end pack up 12 pieces in a blister packaging. The concentration of the active substance of candles varies: 3 pcs. - 50 µg each, 3 pcs. - 100 µg, 3 pcs. - 150 mcg and the same 200 mcg.
  2. A clear, colorless solution without a sharp, peculiar odor is poured into 1 ml ampoules. Each pack contains 10 ampoules, ampoule knife, instructions for use.

The active ingredient of the drug is bacterial lipopolysaccharide. The chemical composition of the drug depends on the form of release:

Pyrogenal release form

Active ingredient, mcg

vaginal suppositories, 1 pc.

bacterial lipopolysaccharide (50, 100, 150 and 200)

cocoa butter, lanolin, purified water

bacterial lipopolysaccharide (10, 25, 50 and 100)

Mechanism of action of the drug

The drug Pyrogenal is an immunomodulator with a wide spectrum of action in the body. The drug with pronounced anti-inflammatory, adjuvant and desensitizing properties increases the overall resistance of the body, controls the thermostatic centers of the hypothalamus, activates fibrinolytic, reticuloendothelial and hypothalamic-pituitary systems.

Upon receipt of a dose of bacterial lipopolysaccharide in the body, the work of the hypothalamus, adrenal cortex, pituitary is activated. The drug interacts with the phagocytic system, triggers the secretion of oxygen radicals and interferon. Other pharmacological properties of Pyrogenal:

  • stimulates the kinin system of the body,
  • accelerates the maturation of fibrocytes,
  • inhibits the synthesis of collagen fibroblasts,
  • accelerates the resorption of scars,
  • increases tissue permeability
  • prevents the development of adhesions (the formation of adhesions),
  • restores damaged nerve tissue
  • improves the fibrinolytic (anticoagulant) properties of blood,
  • stimulates the adrenal glands (increases the level of corticosteroids).

Pyrogenal Candles

The drug in the form of suppositories is administered rectally 1 time per day or every other day. The minimum daily dosage of Pyrogenal is 50 mcg, the maximum is 200 mcg. The recommended course of treatment includes the use of 12 candles according to this scheme: 3 for 50 μg each, 3 for 100 μg each, 3 for 150 μg each and 3 for 200 μg each. In complicated clinical cases, the indicated dosage of the drug is adjusted individually.

Pyrogenal injections

Injections are performed intramuscularly every other day. Before use, a single dose of Pyrogenal is dissolved with 0.9% sodium chloride solution (it is prohibited to store diluted medication). The initial dosage is 2.5 mcg. It is gradually increased by 2.5-5 μg and adjusted to a maximum of 100 μg. The duration of drug therapy varies from 10 to 30 injections. A second course can be taken after a 2-3 month break. Doctors do not exclude the simultaneous use of injections and rectal suppositories Pyrogenal.

special instructions

Pyrogenal medicine is often involved in the fight against alcoholism. The drug causes a steady increase in body temperature, while reducing cravings for alcoholic beverages. Instructions for use contains other recommendations for patients:

  1. In childhood, this medication is used extremely rarely, since clinical studies of this category of patients have not been performed.
  2. Pyrogenal causes dizziness and drowsiness, therefore during the course it is required to temporarily abandon driving, not to engage in work requiring high concentration of attention.
  3. When convulsions and the tendency to such treatment is prescribed under the guise of anticonvulsant therapy exclusively in the hospital.
  4. Patients older than 60 years, the daily dose of Pyrogenal reduced, the treatment proceeds under individual medical supervision.
  5. If the ampoule is opened, it is contraindicated to keep it in the refrigerator. Required to use as intended immediately.

Drug interaction

According to the instructions for use, Pyrogenal is recommended as part of complex therapy, since it can be combined with any drugs. For example, said immunomodulator improves penetration of antibiotics and other chemotherapeutic drugs into affected areas. The main thing is not to combine several medicinal compositions in one syringe.

Solution for injection (optional)

  • Traumatic injuries of the peripheral and central nervous system,
  • Herpes infection of the eye,
  • Slow tuberculosis in the resorption phase,
  • Chronic skin diseases, including psoriasis,
  • Iridocyclitis
  • Corneal opacity,
  • Uveitis,
  • The need for pyrotherapy (as a pyrogenic drug).

Suppositories

In the form of rectal suppositories, Pyrogenal is used rectally.

Single dose - 1 suppository per day. The drug, depending on the prescription, is used daily or every other day.

Single initial / maximum dose - 50/200 mcg.

If there are no other doctor's prescriptions, Pyrogenal suppositories are used with a gradual increase in dose: 50, 100, 150 and 200 mcg, while suppositories of one concentration should be applied 3 times (a total of 12 pieces per course).

If the drug is used as monotherapy for immunorehabilitation and immunoprophylaxis with incomplete recovery after acute bacterial and viral diseases, a concentration of 50 or 100 μg is usually prescribed (5-10 suppositories per course).

As prescribed by the physician, a combined use with the injection of Pyrogenal is possible.

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