Ointment Prednisolone is a pharmacological group of drugs anti-inflammatory drugs for local use. It is used primarily in dermatology for the treatment of various inflammatory pathologies of the skin.
Composition and release form
Ointment Prednisolone has a white color, a viscous consistency and a homogeneous character. The main active ingredient of the drug is prednisone, its content in 1 g of ointment is 0.005 g (0.5% ointment). Also in the composition of the ointment includes excipients, which include:
- White paraffin.
- Stearic acid.
- Emulsifier No. 1.
- Purified water.
Ointment Prednisolone is contained in an aluminum tube in the amount of 10 g. A cardboard box contains one aluminum tube with ointment and instructions for using the preparation.
Pharmacodynamics and pharmacokinetics
Prednisolone is a synthetic analogue of the hormones of the adrenal cortex glucocorticosteroids. When applied locally to Prednisolone ointment, the active ingredient has a pronounced anti-inflammatory effect. Prednisolone inhibits the activity of cycloxygenase 1 and 2 (COX) enzymes, which catalyze the transformation of arachidonic acid into the main mediator of prostaglandin inflammation. This leads to a decrease in the concentration of prostaglandins in the focus of the inflammatory reaction and a decrease in the severity of their biological effects, which include an increase in the permeability of the vessel walls of the microvasculature with the release of blood plasma into the intercellular substance of tissues and their edema, slowing down and an increase in blood flow in the inflamed tissue, stimulation of sensitive nerve endings with the appearance of sensations of discomfort in the form of itching or pain.
After applying the prednisone ointment to the skin, the active component of the drug is practically not absorbed into the systemic circulation.
Indications for use
Ointment prednisone is used to treat inflammatory pathology of the skin of non-infectious origin:
- Eczema is an allergic inflammation that has a chronic course.
- Seborrheic dermatitis is an inflammatory reaction against the background of increased functional activity of the sebaceous glands.
- Psoriasis is a chronic skin disease of a degenerative-dystrophic nature, the origin of which remains not fully elucidated.
- Erythroderma is a skin lesion that develops due to a violation of the functional activity of the immune system.
Also, the drug is used in systemic pathology of the connective tissue of autoimmune origin, which occurs with skin lesions (systemic lupus erythematosus).
There are a number of pathological and physiological conditions of the body, in which the application of ointment Prednisolone is contraindicated:
- Itsenko-Cushing syndrome, characterized by increased production of adrenal hormones glucocorticosteroids.
- The period of vaccine or other immunobiological preparations.
- Some infectious diseases - chickenpox, measles, herpes infection.
- Infectious pathology of the skin of bacterial, viral or fungal origin.
- Secondary syphilis, characterized by the appearance of pathological lesions on the skin.
- Acne, rosacea.
- Cancer pathology of the skin with the formation of benign or malignant tumors on it.
- Violation of the integrity of the skin in the area of the intended application of ointment Prednisolone.
- Individual intolerance to any of the components of the drug.
Before prescribing Prednisolone ointment, the doctor must be sure that there are no contraindications.
Dosage and administration
Ointment Prednisolone is intended for external use. It is applied to the skin in the area of the inflammatory process with a thin layer 1-3 times a day. For adults, depending on the origin, nature and severity of the inflammatory process, the course of treatment varies from 6 to 10 days, but should not exceed 2 weeks. In the case of the use of Prednisolone ointment in children over the age of 1 year, the duration of the course of therapy should not exceed 7 days. Basically, the doctor sets the regimen of use of the drug for the patient individually.
With the external use of Prednisolone ointment, the development of negative pathological reactions on the skin is possible, especially against the background of the presence of individual intolerance to the components of the drug in a patient. These include reddening of the skin (hyperemia), itching, burning, local swelling, rash, an allergic reaction in the form of urticaria (resembles a nettle burn), thinning (atrophy) of the skin and their dryness, the addition of a secondary bacterial or fungal infection. With prolonged use of Prednisolone ointment, the active ingredient may accumulate in the body and lead to the development of systemic negative reactions in the form of hypercorticism (manifestations of increased synthesis of glucocorticosteroids in the adrenal cortex). The appearance of signs of negative reactions is the basis for the withdrawal of the drug or the correction of its dosage.
Before the appointment of Prednisolone ointment, the doctor must ensure that there are no contraindications, and also draws attention to a number of special instructions, which include:
- In order to avoid the development of side effects and negative reactions, it is recommended to use the drug in the lowest possible therapeutic dosage in a short course.
- If you have a history of acute psychosis, suffered in the past, the use of the drug is possible only under medical supervision.
- Cancellation of Prednisone ointment after its long-term use should be carried out with a gradual decrease in dosage for the prevention of withdrawal syndrome, which consists in intensifying the manifestations of the pathological process.
- The maximum allowable skin area to which the application of the drug is allowed should not exceed 20% of the total body surface.
- During treatment, periodic consultations with an ophthalmologist as well as monitoring of systemic blood pressure are necessary.
- With extreme caution, the drug is used for congenital or acquired (HIV / AIDS) immunodeficiency.
- It is not recommended to apply an ointment to prevent recurrence (exacerbation) of the inflammatory process on the skin.
- The use of the drug for children is possible only over the age of 1 year under the supervision of a physician.
- During pregnancy or breastfeeding the use of Prednisolone ointment is not recommended.
- The active component of the drug does not affect the functional state of the central nervous system, the ability to concentrate and the speed of psychomotor reactions.
In the pharmacy network, Prednisolone ointment is dispensed only by prescription. Self-administration of the drug without appropriate medical prescription is excluded.
With a significant excess of the recommended therapeutic dose of Prednisolone ointment, the appearance or enhancement of side effects may occur. With prolonged use of the drug with its application to large areas of the skin, systemic exposure in the form of hypercorticism is possible. Treatment of overdose is symptomatic, it is prescribed by the attending physician.
Composition and action
This is a one-component drug, contains the same active substance - prednisolone sodium phosphate. The concentration is 0.5%. Additionally, the composition includes auxiliary substances:
- distilled glycerin,
- stearic acid
- emulsifier No. 1,
- methyl parahydroxybenzoate,
- propyl parahydroxybenzoate,
The ointment is applied externally. Components in its composition are involved in many biochemical processes of the body.
Pharmacological properties of ointment Prednisolone
The drug is marketed as an anti-inflammatory agent. It also has antiallergic, immunosuppressive effects, helps to stop the formation and exudate secretion.
The drug is marketed as an anti-inflammatory agent. It also has antiallergic, immunosuppressive effects, helps to stop the formation and exudate secretion.
Despite the fact that the ointment is a group of external preparations, it is absorbed when applied to the affected skin. As a result, the active substance enters the bloodstream. At this stage, prednisolone sodium phosphate is not transformed. Most of it (90%) is in a bound form. Biotransformation component occurs in the liver. After oxidation, the released forms are sulfated, glucuronized. Metabolites are excreted by urination, during defecation.
The indication for the use of funds is an inflammatory process of different etiology.
What is it used for?
The indication for applying the ointment is the development of the following pathological conditions:
- various skin diseases: neurodermatitis, lichen, seborrheic and allergic dermatitis, lupus erythematosus, psoriasis, toxidermia, eczema,
- keloid scars
- non-infectious eye diseases,
- diseases of the musculoskeletal system: humeroscapular periarthritis, bursitis, tendosynovitis, epicondylitis.
The indication for the use of funds is an inflammatory process of different etiology.
Ointment Prednisolone for hemorrhoids
The drug can be appointed in the final stages of the development of nodes. Hormonal ointments are recommended if non-steroidal agents have not provided the desired result. This medicine helps to eliminate the symptoms of the inflammatory process: swelling, pain, local fever. In addition, the intensity of exudation decreases, oozing disappears, which contributes to the drying of damaged outer integuments.
What kind of ointment and what helps
Prednisolone ointment or cream is a hormonal drug (GCS). It is characterized by a pronounced anti-inflammatory and antiallergic action.
It is used to restore connective tissue in the treatment of systemic diseases.
GCS in the form of prednisone cream eliminates such unpleasant symptoms as:
- Collagen deposition.
- Pain sensations.
With photophobia, capillary permeability and photosensitivity appears as prednisone eye ointment. It is widely used in dermatology for the treatment of chronic and acute pathological processes. Designed for outdoor local application.
Active ingredient and composition
The main active ingredient - prednisone - a dehydrated corticosteroid of moderate strength, produced by the adrenal cortex. The concentration in the preparation is 0.05 g.
Auxiliary substances included in the composition:
- white soft paraffin
- distilled water,
- stearic acid
- methyl and propyl paraben,
- No. 1 emulsifier.
The composition of the additional substances may vary from different manufacturers of the product.
In childhood, during pregnancy and HB
The cream is approved for use by children from 24 months, when used in the anal area - from 12 years. When taking into account the fact that prednisone GCS, the duration of treatment differs from the dosage of an adult.
During pregnancy and during breastfeeding, it is not recommended to use the drug, because the effect of the drug on the fetus and mother has not been established.
The basis for using the agent in these cases is considered as a vital indicator.
Release form and composition of the ointment Prednisolone
Prednisolone is produced in the form of a topical ointment in tubes of 10, 15 g, packed in cardboard boxes, each of which contains an abstract. The active substance of the hormonal drug is the prednisone component of the same name. Auxiliary substances in the composition of the ointment are:
- emulsifier 1,
- stearic acid
- propyl paraben,
- purified water.
Prednisolone is a hormone of the adrenal cortex, which suppresses the functional activity of tissue macrophages and leukocytes, restricting their migration to the site of inflammation. The substance has the ability to reduce the permeability of blood capillaries due to the release of histamine. This inhibits the formation of collagen and fibroblast activity. Prednisolone in liver cells enhances glucose synthesis from protein metabolism and glycogen synthetase activity. High absorbability is noted 90 minutes after applying the ointment. The drug is excreted unchanged by the kidneys. In large doses, prednisone increases the excitability of brain tissue.
What helps ointment: indications for use
According to the instructions for use, Prednisolone ointment (international name of the drug: Prednisolone) is prescribed for non-infectious skin lesions, characterized by weeping, itching, rash:
- Seborrheic, atopic dermatitis.
- Lupus erythematosus.
- Restricted, diffuse atopic dermatitis.
- Rectal fissures, hemorrhoids.
- Swelling of the subcutaneous tissue.
- Skin manifestations of allergies.
- Full or partial alopecia.
- Inflammatory diseases of the eye.
- Allergic rhinitis.
Dosing and Administration
Prednisolone treatment is carried out externally. The ointment is applied with a thin layer on the affected area 1-3 times a day. The course of drug treatment prescribed by the doctor individually. According to the instructions, the average duration of therapy is 1-2 weeks. The use of Prednisolone ointment at the end of the course should be halved so that no overdose occurs. In chronic pathology, long-term therapy is allowed under the supervision of a physician, and it must be continued for several days after all symptoms have been eliminated to prevent a possible recurrence. It is allowed to use ointment under the dressing to improve the therapeutic effect.
Contraindications and side effects
Do not forget that hormonal ointment, so the effects of the use of the drug Prednisolone may be accompanied by unpleasant side reactions of the body. Among them, excessive hair on the skin, impaired immunity, viral diseases, stretch marks due to the destruction of collagen, excessive pigmentation, dry skin, steroid acne, folliculitis, erythema.
Do not use Prednisone ointment for skin tuberculosis or syphilitic lesions. The absolute contraindications of the drug also include skin tumors, bacterial infections, viral pathologies caused by skin lesions, ulcers of the digestive organs, and intolerance to ointment substances. If the patient suffers from any of the above diseases, the doctor should replace Prednisone with another drug.
Application for children and pregnant women
Prednisone in pregnancy in any form is prohibited. In extreme cases, the gynecologist may make an exception if the benefit for the woman exceeds the risks of the negative impact of the steroid on the development of the fetus. The active substance of the ointment is very quickly absorbed through the placenta, and then excreted along with the mother's milk, therefore, during lactation, feeding of the baby must be stopped. Ointment Prednisolone children prescribed from one year. But hormonal drug therapy is carried out under the supervision of a pediatrician. You should not allow uncontrolled use of the hormone, the total duration of which should not be more than 7 days.
What to replace Prednisolone ointment: analogues
- Fuzime. The ointment is prescribed for the treatment of purulent-inflammatory processes of the skin: furunculosis, impetigo, folliculitis. superficial abrasions and wounds. Effective drug in the treatment of burns 1-2-4 stage.
- Petroleum Non-steroidal substitute Prednisolone, prepared from refined oil according to homeopathic rules. It is indicated for chronic skin diseases: eczema, neurodermatitis. It shows good results in the treatment of rheumatism, sprains, cracks in the skin, and a pathologically unpleasant smell of sweat.
- Decortin. Effective with systemic diseases: rheumatoid arthritis, dermatomyositis, periarteritis nodosa. It is prescribed for use in ankylosing spondylitis, bursitis, rheumatic fever.
Elena, 31 years old: At the pharmacy, Prednisolone read the indications for using the ointment and decided to buy an inexpensive dermatitis preparation on the face. Ointment for a few days helped get rid of the rash on the cheeks and redness on the wings of the nose. Judging by the description, the drug is effective and with neurodermatitis, eczema, itching, and it costs only a little more than 50 rubles.
Alexander, 34 years old: This is the best remedy for dry eczema, which has been tormenting me for several years. In the spring-winter period, my skin begins to peel off on various parts of the body, and then the symptoms turn into pain, bleeding, itching, and burning. After I started using Prednisolone ointment after 2 days I felt better, and after 2 weeks the eczema disappeared. Before that, he suffered from this sore from September to April.
The drug is applied to the skin 1-3 times a day. The frequency of application depends on the state of the integument, the intensity of the manifestations of the disease. The course of treatment lasts from 6 to 14 days. If during this time the symptoms have not disappeared, therapy is continued. However, with prolonged use, the dosage amount of ointment decreases. Иногда используют окклюзионные повязки, что позволяет повысить эффективность лекарства.
При беременности и лактации
Препарат используют выборочно. В 1 триместре мазь может назначаться, только если вероятная польза превосходит возможный вред. Prolonged use during pregnancy can lead to fetal developmental disorders. In addition, sometimes atrophy of the adrenal cortex develops as a result of hormonal ointment therapy, which leads to a loss of the ability to produce hormones on their own.
The active substance passes into breast milk. This means that during the lactation period, another drug should be selected or the feeding should be interrupted.
Use in childhood
The ointment is used to treat patients 1 year and older. However, treatment of children prescribed with a small amount of funds. The general course should be short. At the same time exclude additional funds that can enhance the effect of the drug: warming compresses, occlusive dressings.
With the simultaneous use of different drugs, the following effects are noted:
- increases the effect of anticoagulants,
- when using salicylates (part of Aspirin and other painkillers), the likelihood of bleeding increases,
- during the use of prednisone ointment and diuretics increases the risk of electrolyte metabolism,
- glucoside intoxication may occur,
- Rifampicin's activity decreases, and the hypoglycemic effect of drugs used in diabetes mellitus decreases,
- Prednisolone ointment is not used along with antacids.
When choosing a medicine, drugs of a new generation and common substitutes are considered. The form of release may be different: tablets, solution in ampoules, ointment, cream, gel. The choice is made based on the principle of action and composition.
Among the substitutes - Medopred. This tool is made in ampoules, costs a little more expensive (145 rubles). Its active ingredient is also prednisolone sodium phosphate. The drug is positioned as a glucocorticosteroid agent. It shows anti-inflammatory activity, helps to eliminate the signs of shock, allergies. Additionally Medopred has an immunosuppressive effect.
This medicine is prescribed for acute allergic conditions. With it, pathologies such as thyrotoxic crisis, myocardial infarction, shock, adrenal dysfunction in the acute phase, liver cirrhosis, hepatic and renal failure, chemical poisoning are treated. This drug has a large number of negative reactions from most organs and body systems. Mark and many contraindications.
Another analogue is Sinaflan. It is produced as an ointment. The drug is intended for external use. This medicine is in the same price category as prednisone ointment. Average cost - 70-80 rubles. The main component in the composition - fluocinolone acetonide. This tool also represents a group of glucocorticosteroids. Its properties: anti-inflammatory, antipruritic, anti-allergic.
Analogue Prednisolone - Sinaflan. It is produced as an ointment, represents a group of glucocorticosteroids. It is an anti-inflammatory, antipruritic, anti-allergic agent.
Indications for use:
- inflammatory processes of different etiology,
- allergic diseases affecting the integuments,
The drug has contraindications: the period of carrying the child, the integrity of the outer integument, ulcerative lesions, infections of a viral, fungal, bacterial nature with manifestations on the surface of the skin. With prolonged use may develop systemic side effects, atrophy of the treated tissue.
Varieties, names, release forms and composition of Prednisolone
All medicines that have the word "Prednisolone" in the title contain as active ingredient as glucocorticoid prednisone
Currently, doctors, pharmacists and patients under the name "Prednisolone" mean the entire set of drugs containing prednisone as an active substance. These drugs are sold under different commercial names, many of which have been registered in the CIS countries over the past 20 years, because before that there was a practice of manufacturing drugs containing the same active substance by various pharmaceutical factories in cities and republics of the USSR under the same the same name. That is, for example, a drug containing prednisone was produced at a pharmaceutical plant in Nizhny Novgorod, Samara, Tomsk and other cities, but was always sold in pharmacies under the same name "Prednisone".
Today, many pharmaceutical plants, wishing to protect the drug they produce, register it under a different name, for example, Prednisol, Medopred, etc. This is done so that people, doctors and pharmacists can quickly navigate what kind of "prednisone" is produced by one or another plant. This is convenient, because some drugs for some subjective reasons people may like more than others. Knowing the commercial name of such a "good" prednisolone, you can immediately acquire it, and not look in the pharmacies "Prednisolone" of the production of a particular plant.
Today, drugs containing prednisone are marketed and sold under the following commercial names:
- Decortin N20, Decortin N5 and Decortin N50,
- Prednisone Bufus,
- Prednisolone hemisuccinate,
- Prednisolone Sodium Metasulfobenzoate,
- Prednisolone sodium phosphate,
- Prednisolone ointment,
- Sol-Decortin N25, Sol-Decortin N50 and Sol-Decortin H250.
In the further text of the article we will understand as Prednisolone all medicines containing the hormone prednisone as an active substance, regardless of their commercial names.
Prednisolone preparations are available in five dosage forms:
- Oral tablets,
- Solution for intravenous and intramuscular injections,
- Powder for solution for injection,
- Ointment for external use,
- Drops or suspension for eyes.
Tablets contain 5 mg and 1 mg of prednisolone, solution - 30 mg per 1 ml and 15 mg per 1 ml, powder - 30 mg per vial, ointment - 0.5% and eye drops - also 0.5%. As auxiliary components, preparations of the same dosage form (for example, tablets) may contain different substances if manufactured by different factories. Therefore, a detailed and accurate composition of the auxiliary components should be viewed on the package or in the package leaflet with the instructions attached to the specific preparation.
The prescription for Prednisolone tablets is as follows:
Rp .: Tab. Prednisoloni 0.001 (or 0.005)
D. t. d. N 50 in tabletae
S.Po 1 tablet 3 times a day.
The prescription for prednisolone ointment is as follows:
Rp .: Ung. Prednisoloni 0,5%
D. S. Apply on the affected areas 1 to 2 times a day.
The prescription for prednisone eye drops is as follows:
Rp .: Sol. Prednisoloni 0,5%
D. S. Introduce 1 to 2 drops 2 to 3 times a day into the conjunctival sac.
The prescription for Prednisolone injection solution is as follows:
Rp .: Sol. Prednisoloni 3% (30 mg / ml)
D. t. d. N 10 inamp.
S. Administer intravenously 1 - 2 times a day.
In all recipes after the letters "Rp." the name of the medicinal form of the drug is indicated (Sol - solution, Ung – ointment, Tab – tablet) and the name of the drug is written in Latin (Prednisoloni). After the name of the drug indicates the concentration of the active substance, that is, the dosage. On the next line after the letters "D. t." It indicates the amount of the drug to be given to the person (for example, No. 50 intablet means that the person needs to release 50 tablets, etc.). After the letter "S" indicates how to use the drug. This recipe line is for the person who will use Prednisolone.
Effects of Prednisolone (therapeutic effect)
Prednisolone with systemic (pills and injections), topical (eye drops) and topical (ointment) has the following therapeutic effects:
- Anti-inflammatory effect, which is the rapid and effective relief of the inflammatory process of any localization and intensity,
- Antiallergic action, which is the rapid cessation of the development of an allergic reaction and its manifestations, such as spasm, swelling, rashes on the skin, etc.,
- Anti-shock action, which is to relieve shock in order to prevent death,
- Antiexudative action, which is to suppress the active process of exudation (effusion of inflammatory fluid from the tissues),
- Antiproliferative effect, which is to suppress the active reproduction of cells in the damaged area, which prevents the formation of cicatricial thickening of the walls of organs,
- Antipruritic action, which consists in eliminating the itching sensation provoked by allergic or inflammatory reactions,
- Immunosuppressive action, which is to suppress the immune system and the creation of artificial immunodeficiency.
All clinical effects of Prednisolone are important for clinical use, with the exception of immunosuppressive, which is considered more likely to be a side effect. Therapeutic effects develop very quickly, which allows you to use the drug in critical situations, when you need to literally within 5 - 10 minutes to normalize the human condition, stopping the further development of massive edema, spasm of the respiratory organs and inflammatory infiltration of the organ wall.
Since Prednisolone has a very powerful effect, it is used only in severe cases when other drugs (for example, nonsteroidal anti-inflammatory drugs, antihistamines, etc.) do not have the desired effect. If it is possible to maintain a normal state and prevent the disease from getting worse, not with Prednisone, but with other, more “weak” drugs, then this should be done. Prednisolone should be used only in cases when other drugs are ineffective or a life-threatening condition has arisen (for example, angioedema, anaphylactic shock, bronchospasm, etc.), which must be removed very quickly.
In addition to the listed therapeutic effects, Prednisolone can have the following pharmacological effects:
- Increases protein breakdown, reducing its concentration in plasma and tissues,
- Increases protein synthesis in the liver,
- Suppresses active growth in children by increasing the breakdown of proteins,
- It leads to the redistribution of fat, increasing its deposition on the face and upper body,
- Increases blood glucose levels
- Detains in the body water and sodium, which contributes to the formation of edema,
- Excretes potassium from the body and reduces its absorption in the intestines,
- Increases the excitability of the brain,
- Reduces the threshold of convulsive readiness, as a result of which convulsions can develop in a person more often when exposed to stimuli of relatively low strength,
- Inhibits the synthesis of glucocorticosteroids own adrenal glands,
- It inhibits the synthesis of thyroid-stimulating and follicle-stimulating hormone (TSH and FSH).
These pharmacological effects are almost never used for therapeutic purposes, but since they are the basis of side effects, they are always taken into account for an adequate assessment of the state of the body against the background of Prednisolone.
Instructions for use
Regarding the use of any form of Prednisolone, you should use the following simple and immutable rule - use the drug in the lowest effective dose and for the shortest possible time, which is enough to relieve an acute condition. Remember that Prednisolone is a drug of "acute conditions", and it is not intended for long term use due to numerous, very dangerous and serious side effects. Therefore, after the relief of the acute state of Prednisolone, you should switch to taking other drugs intended for course use.
Consider the rules for the use of various dosage forms of Prednisolone separately.
Prednisolone tablets - instructions for use
The tablets are washed down with a small amount of water, swallowing whole, not chewed or chewed. Prednisolone tablets should be taken in the morning from 6-00 to 8-00 in the morning, strictly after meals. If at this time it is impossible to take the drug, then it should be done before 12-00, because it is in the morning hours that Prednisolone has the most pronounced therapeutic effects. If you can take the entire daily dose of the drug at a time in the morning, you should do so. If for some reason this is not possible, then most of the daily dose (at least 2/3) should be taken in the morning, and the remaining amount should be around 12-00.
At the beginning of the treatment of acute and severe conditions, you should take 50 - 75 mg (10 - 15 tablets) per day, and chronic diseases - 20 - 30 mg per day (4 - 6 tablets). After the state is normalized, the dosage of Prednisolone is reduced to 5-15 mg per day and the tablets are continued. The duration of treatment is determined by the doctor, and depends on the general condition of the person and the effectiveness of therapy.
For children, the dosage is calculated individually by body weight, based on a ratio of 1–2 mg per 1 kg of weight to start treatment, and 0.25– 0.5 mg / kg for a maintenance dose.
Prednisolone ampoules - instructions for use
The solution can be administered intramuscularly, intravenously or intra-articularly. The dosage and method of administration of Prednisolone injections are determined by the doctor individually in each case, taking into account the type of pathology, the location of the affected organ and the presence of a possible period of time for relief of severe symptoms. In the course of treatment, the dosage and method of administration of the solution may vary depending on the response of the person to therapy.
The best way to administer Prednisolone solution is by intravenous injection. This means that for various diseases and conditions, the method of choice for administering the solution is intravenous. Intramuscular Prednisolone should be administered only when it is impossible to perform an intravenous injection. Intra-articular administration of Prednisolone is indicated exclusively for diseases and conditions in which the tissues inside the joint are affected.
When the swelling, inflammation and exudation of the joint diminish, Prednisolone injections can be replaced with pills that should be taken until the development of stable remission.
Since normally in the human body, the adrenal glands emit glucocorticoid hormones in the blood between 6-00 and 8-00 in the morning, and injections should be made at the same time. That is, the optimal time for injecting the solution is between 6-00 and 8-00 in the morning. It is recommended to administer the entire dosage of the hormone at a time in the morning. If, for any reason, the entire daily dose of Prednisolone is not possible at once, then in the morning you should introduce most of it (at least 2/3), and at lunchtime (12-00) the remaining amount.
When shocked, 50-150 mg of Prednisolone (2-5 ml of 3% (30 mg / ml) solution) are administered at once. Re-enter the same amount of solution every 3 to 4 hours during the first day. After that, the doctor determines whether there is a need to continue Prednisolone injections or they can be stopped. In case of acute insufficiency of the adrenal glands and liver, as well as in allergic reactions, 100 to 200 mg of Prednisolone is administered every 8 hours. In asthmatic status, 500-1,200 mg of Prednisolone are administered once, on the second day the dosage is reduced to 300 mg, on the third to 150 mg and on the fourth to 100 mg. On the 5th - 6th day, Prednisolone can be canceled if the asthmatic status is no longer repeated.
For children, the daily dosage is calculated individually, depending on age and body weight:
- Children 2 - 12 months - 2 - 3 mg per 1 kg of weight,
- Children 1 - 14 years old - at 1 - 2 mg per 1 kg.
Prednisolone in the indicated dosages is administered once, and in the absence of effect, within 20 to 30 minutes - repeatedly. More during the day is not allowed the introduction of Prednisolone.
The dosage of Prednisolone for intraarticular injection is determined by the size of the joint:
- Large joints - 25 to 50 mg,
- Medium-sized joints - 10 - 25 mg,
- Small joints - 5-10 mg.
How to make injections of prednisolone
Intravenous injection of prednisolone is performed in two ways - by jet and drip ("dropper"). And in the first hours after the development of an acute condition, Prednisolone is injected in a jet, that is, a vein is punctured, a needle is inserted into it and a solution is released from the syringe. Such a jet injection of the solution is continued until a very rapid effect is necessary. After partial normalization of the human condition, they switch to the prednisolone drip (“dropper”). To do this, the required amount of Prednisolone solution is mixed with saline in a volume of 250-500 ml and injected at a rate of 15-25 drops per minute.
Intramuscular injection is made by the general rules. That is, the solution is injected into the outer-lateral upper part of the thigh, the upper third of the shoulder, or into the stomach, if the person is slim. Перед введением область инъекции протирается антисептиком, после чего раствор набирается в шприц, и игла вводится глубоко в ткани перпендикулярно к коже. Надавливанием на поршень раствор выпускается в мышцу, игла достается, и кожа снова протирается антисептиком.
Применение при беременности
Prednisolone during pregnancy can be used only if there is a threat to the life of the mother, since Prednisolone has a teratogenic effect. In experiments on rats and mice, the development of a wolf's mouth in pups born to a mother who received Prednisolone during pregnancy was shown.
When breastfeeding Prednisolone should also not be used, since the hormone enters the milk and can affect the body of the child. Therefore, if necessary, the use of Prednisolone in nursing mothers should transfer the child to an artificial mixture.
Prednisone for children
In children, Prednisolone is used only when it is urgently needed, when there is a threat to life or a serious illness that is not amenable to treatment with other medicines. When using tablets and Prednisolone solution in children younger than 14 years old, an intermittent scheme should be used, which consists in taking the drug for 3 days, after which a break for 4 days, etc. Such an intermittent scheme allows to reduce the risk of cessation of growth and development of the child. When using the ointment, you can not additionally carry out activities that enhance the absorption of the drug into the blood (for example, heating, tight bandages, etc.). The rest of the rules of application and precautions for children are the same as for adults.
The dosage of ointment and eye drops Prednisolone for children is the same as for adults. And the dosage of tablets and solution is calculated individually depending on body weight and age. The initial dosage of tablets, which the child takes within 1 to 2 days to relieve an acute condition, is calculated from the ratio of 1 to 2 mg per 1 kg of body weight. This dosage is divided into 4 - 6 doses per day. After the acute condition is normalized, the child is transferred to the maintenance dosage of Prednisolone, which is calculated by the ratio of 0.3-0.6 mg per 1 kg of weight per day.
The daily dosage of the solution is calculated individually depending on the age and body weight:
- Children 2 - 12 months - 2 - 3 mg per 1 kg of weight,
- Children 1 - 14 years old - at 1 - 2 mg per 1 kg,
- Over 14 years old - adult dosages.
After prednisolone (edema, excess weight)
After completing the course of Prednisolone, people very often notice the appearance of edema on the face, excess weight in the abdomen, hands, neck and face, as well as atrophy of the muscles of the hips and buttocks. Unfortunately, Prednisolone can really provoke weight gain and muscle atrophy, which, after the end of its use, will not go away on its own and will have to make an effort to restore normal form. The weight can be reduced, and the muscles can be trained, regularly practicing in the hall and eating right. There is no other way to return the form.
With enough perseverance in attending the gym and regular workouts, many people note that even during the course of Prednisolone, they do not gain weight. The only point that can not be controlled is the deposition of fat on the face with the formation of a moon-shaped form. However, to stop the deposition of fat on the face is really almost impossible, so you have to accept it. Some time after stopping the use of Prednisolone, the fat from the face will go away on its own.
As for edema, they are possible only on the background of Prednisone therapy. After completing the course of treatment, human swelling should not be disturbed if there is no disease capable of provoking them. However, the deposition of fat on the face during the course of Prednisolone leads to an increase in the amount of subcutaneous tissue in the cheeks, orbits and other parts, which is filled with blood during sleep, resulting in a slight increase in its mass and volume. And it is this increased amount of soft tissues people take for edema.
During the day, the blood flows from the adipose tissue of the face under the action of gravity, and this “swelling” for dinner or dinner is gone. Many people are worried about this "swelling" because they think that this is a symptom of some kind of distress in the body. However, this is not true, and this behavior of the subcutaneous fatty tissue on the face is the price for the vital treatment. With regular training and proper nutrition for several months, there will be a general weight loss, and the amount of fatty tissue will decrease on all parts of the body, including on the face. And only after that the "swelling" will begin to pass.
Prednisolone is a thick white ointment without any peculiar smell. It is well absorbed by the skin, and the ingredients quickly penetrate into the pathological foci. The tool has a therapeutic effect a few minutes after its application. The hormonal drug is used to treat acute and chronic skin diseases. It eliminates almost all clinical manifestations of pathologies of allergic origin. What helps Prednisolone ointment to:
- swelling and redness of the epidermis, the cause of which was the development of the inflammatory process,
- burning, soreness, itchy skin,
- large and small rashes,
- profuse exfoliation of the upper epidermal layer.
The drug is included in the therapeutic regimen only by the attending specialist. He is studying the patient’s history and biochemical analysis results. The dermatologist necessarily takes into account the degree of tissue damage, the stage of the pathological process.
Terms and conditions of storage
The drug is stored in a dark place at a temperature of 5-15 ° C. Shelf life - 24 months. In case of violation of the temperature regime, the ointment is stratified, its color and smell change. This indicates the unsuitability of Prednisolone for treatment. After opening the tube, it is necessary to use its contents within a month. Access to medicine for young children should be limited.
Indications and contraindications
Ointment with prednisolone successfully treats chronic pathologies that are exacerbated by negative factors. It is prescribed to patients with localized neurodermatitis. In this case, the antiproliferative activity of the agent is used, which is manifested in slowing down cell division. Hormonal drugs are included in treatment regimens for diagnosing the following diseases:
- contact, atopic dermatitis,
- discoid lupus erythematosus,
- psoriatic lesions (papules, plaques),
- dry and moist eczema of any location,
- seborrheic dermatitis,
- acutely flowing urticaria.
Prednisone is not prescribed to patients in the presence of microtraumas in the area (cracks, scratches, abrasions, cuts). It is prohibited for use during the period of carrying a child and during lactation. In pediatrics, ointment is used to treat children older than one year. Contraindications to therapy are syphilitic, tuberculosis, acne. The hormonal agent is not intended for the treatment of inflammation of fungal, viral, bacterial origin.
Prices and terms of holidays from pharmacies
Prednisolone does not apply to drugs dispensed from pharmacies by prescription. Its average cost is 20 rubles. In the pharmacy assortment, a new generation of ointments with similar therapeutic properties appeared. They are combined with medicines in various dosage forms - tablets, injections, syrups, suspensions. Means with active ingredients hydrocortisone, betamethasone, dexamethasone have a similar pharmacological action.
The current analogues of Prednisolone ointment are Akriderm, Triderm, Belosalik, Locoid cream (manual), Uniderm.
Composition and pharmacokinetics
Prednisolone ointment has a therapeutic effect due to the content in it of the active substance prednisolone, which has a positive effect on damaged skin.
Prednisolone is absorbed into the skin and then enters the bloodstream, where 90% of it is bound to blood proteins, and then biotransformed in the liver and subsequently excreted in feces and urine. The half-life is 200 minutes.
100 gr. The drug contains prednisone 0.5 g. In addition to the drug, there are also adjuvants: water, glycerol, medical petrolatum, nipangin, stearic acid, nipazol.
Prednisolone has an overwhelming effect on the function of leukocytes and tissue macrophages that destroy microorganisms, stabilizes lysosomal membranes, improves the condition of damaged cells, and reduces capillary permeability.
Prednisolone ointment is available in tubes or glass jars of 10, 15, 25 and 30 grams. Keep it in a cool place. Dispensed from pharmacies by prescription.
(Leave your feedback in the comments)
[su_quote cite = "Klara, Moscow"] For me, prednisolone ointment is the first remedy for healing cracks, although many acquaintances were against its use - this is a hormonal drug! I have never had side effects. [/ su_quote]
[su_quote cite = "Alice, MO"] I decided to try this ointment after the advice of my cosmetologist to combat the subcutaneous pimple - this is when the sebum secretion of the skin is thick and cannot go through the duct. It resolves very long. Apply the ointment should have been dotted on the pimple. The best effect is observed when using the ointment for early manifestation of a pimple - it helps well. A great option for a couple of pimples. [/ su_quote]
[su_quote cite = "Lola, St. Petersburg"] I found out about this tool by chance from my mother. She was helped by prednisone to get rid of an allergy to another drug - improvements appeared right before our eyes, itching and rash were gone. My sister also uses this pimple ointment. And I myself daughter, when sweetie pereest, remove her allergies. I advise everyone, but use caution - there are contraindications. And most importantly - it is cheap. [/ su_quote]
* - The average value among several sellers at the time of monitoring is not a public offer.